Acute- and insidious-onset myelopathy of undetermined aetiology

contribution of paraclinical tests to the diagnosis of multiple sclerosis

M. Filippi, V. Martinelli, T. Locatelli, S. Medaglini, A. Poggi, A. Visciani, G. Scotti, N. Canal, G. Comi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Brain magnetic resonance imaging (MRI), multimodality evoked potentials (EPs) and cerebrospinal fluid examination were performed in 42 patients with myelopathy of undetermined aetiology in order to detect abnormalities usually related to multiple sclerosis (MS). Patients were divided into three groups: insidious-onset myelopathy with only motor signs (group A; 11 patients), with both motor and sensory signs (group B; 18 patients) and acute-onset myelopathy (group C; 13 patients). Multiple brain MRI lesions were found in 18 patients (2 of group A, 13 of group B and 3 of group C). Another 7 patients had a single white-matter lesion. Visual EPs were abnormal in 21 and brain-stem auditory EPs in 12 patients. Paraclinical tests supported the diagnosis of MS in 25 patients (60%) by showing subclinical brain abnormalities. Oligoclonal bands were found in 16 of these 25 patients. The findings strongly suggest a diagnosis of MS in the patients of group B.

Original languageEnglish
Pages (from-to)171-176
Number of pages6
JournalJournal of Neurology
Volume237
Issue number3
DOIs
Publication statusPublished - Jun 1990

Fingerprint

Spinal Cord Diseases
Multiple Sclerosis
Brain
Magnetic Resonance Imaging
Oligoclonal Bands
Visual Evoked Potentials
Brain Stem Auditory Evoked Potentials
Evoked Potentials
Cerebrospinal Fluid

Keywords

  • Evoked potentials
  • Magnetic resonance imaging
  • Multiple sclerosis
  • Myelopathy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Acute- and insidious-onset myelopathy of undetermined aetiology : contribution of paraclinical tests to the diagnosis of multiple sclerosis. / Filippi, M.; Martinelli, V.; Locatelli, T.; Medaglini, S.; Poggi, A.; Visciani, A.; Scotti, G.; Canal, N.; Comi, G.

In: Journal of Neurology, Vol. 237, No. 3, 06.1990, p. 171-176.

Research output: Contribution to journalArticle

@article{e901e6418ad14dcaab0aec92221d7658,
title = "Acute- and insidious-onset myelopathy of undetermined aetiology: contribution of paraclinical tests to the diagnosis of multiple sclerosis",
abstract = "Brain magnetic resonance imaging (MRI), multimodality evoked potentials (EPs) and cerebrospinal fluid examination were performed in 42 patients with myelopathy of undetermined aetiology in order to detect abnormalities usually related to multiple sclerosis (MS). Patients were divided into three groups: insidious-onset myelopathy with only motor signs (group A; 11 patients), with both motor and sensory signs (group B; 18 patients) and acute-onset myelopathy (group C; 13 patients). Multiple brain MRI lesions were found in 18 patients (2 of group A, 13 of group B and 3 of group C). Another 7 patients had a single white-matter lesion. Visual EPs were abnormal in 21 and brain-stem auditory EPs in 12 patients. Paraclinical tests supported the diagnosis of MS in 25 patients (60{\%}) by showing subclinical brain abnormalities. Oligoclonal bands were found in 16 of these 25 patients. The findings strongly suggest a diagnosis of MS in the patients of group B.",
keywords = "Evoked potentials, Magnetic resonance imaging, Multiple sclerosis, Myelopathy",
author = "M. Filippi and V. Martinelli and T. Locatelli and S. Medaglini and A. Poggi and A. Visciani and G. Scotti and N. Canal and G. Comi",
year = "1990",
month = "6",
doi = "10.1007/BF00314590",
language = "English",
volume = "237",
pages = "171--176",
journal = "Journal of Neurology",
issn = "0340-5354",
publisher = "Dr. Dietrich Steinkopff Verlag GmbH and Co. KG",
number = "3",

}

TY - JOUR

T1 - Acute- and insidious-onset myelopathy of undetermined aetiology

T2 - contribution of paraclinical tests to the diagnosis of multiple sclerosis

AU - Filippi, M.

AU - Martinelli, V.

AU - Locatelli, T.

AU - Medaglini, S.

AU - Poggi, A.

AU - Visciani, A.

AU - Scotti, G.

AU - Canal, N.

AU - Comi, G.

PY - 1990/6

Y1 - 1990/6

N2 - Brain magnetic resonance imaging (MRI), multimodality evoked potentials (EPs) and cerebrospinal fluid examination were performed in 42 patients with myelopathy of undetermined aetiology in order to detect abnormalities usually related to multiple sclerosis (MS). Patients were divided into three groups: insidious-onset myelopathy with only motor signs (group A; 11 patients), with both motor and sensory signs (group B; 18 patients) and acute-onset myelopathy (group C; 13 patients). Multiple brain MRI lesions were found in 18 patients (2 of group A, 13 of group B and 3 of group C). Another 7 patients had a single white-matter lesion. Visual EPs were abnormal in 21 and brain-stem auditory EPs in 12 patients. Paraclinical tests supported the diagnosis of MS in 25 patients (60%) by showing subclinical brain abnormalities. Oligoclonal bands were found in 16 of these 25 patients. The findings strongly suggest a diagnosis of MS in the patients of group B.

AB - Brain magnetic resonance imaging (MRI), multimodality evoked potentials (EPs) and cerebrospinal fluid examination were performed in 42 patients with myelopathy of undetermined aetiology in order to detect abnormalities usually related to multiple sclerosis (MS). Patients were divided into three groups: insidious-onset myelopathy with only motor signs (group A; 11 patients), with both motor and sensory signs (group B; 18 patients) and acute-onset myelopathy (group C; 13 patients). Multiple brain MRI lesions were found in 18 patients (2 of group A, 13 of group B and 3 of group C). Another 7 patients had a single white-matter lesion. Visual EPs were abnormal in 21 and brain-stem auditory EPs in 12 patients. Paraclinical tests supported the diagnosis of MS in 25 patients (60%) by showing subclinical brain abnormalities. Oligoclonal bands were found in 16 of these 25 patients. The findings strongly suggest a diagnosis of MS in the patients of group B.

KW - Evoked potentials

KW - Magnetic resonance imaging

KW - Multiple sclerosis

KW - Myelopathy

UR - http://www.scopus.com/inward/record.url?scp=0025280043&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025280043&partnerID=8YFLogxK

U2 - 10.1007/BF00314590

DO - 10.1007/BF00314590

M3 - Article

VL - 237

SP - 171

EP - 176

JO - Journal of Neurology

JF - Journal of Neurology

SN - 0340-5354

IS - 3

ER -