Abstract
Catechol-O-methyltransferase (COMT) inactivates norepinephrine and dopamine via methyl conjugation, and a G-A transition in the COMT gene (rs4680) influences the enzyme activity. It is a current area of debate whether rs4680 can influence antidepressant response in major depressive disorder, and whether this influence extends to bipolar depression. Chronotherapeutic interventions, such as sleep deprivation and light therapy, are multi-target in nature and are effective in bipolar depression. Here we studied the effect of rs4680 on response to sleep deprivation combined with light therapy (36 h awake followed by a night of undisturbed sleep, with 10,000 lx light administered for 30 min during the night awake and upon awakening) in 87 bipolar depressed inpatients. Patients who were homozygotic for the Val/Val variant showed a significantly less efficient antidepressant effect after the night awake than those who were heterozygotic and homozygotic for the Met variant. This effect of rs4680 is similar to its observed influence on response to serotonergic and noradrenergic drug treatments in major depressive disorder. This is the first study reporting an influence of rs4680 on antidepressant response in bipolar depression. This finding supports the hypothesis of a major role for catecholamines in the mechanism of action of chronotherapeutics, and for rs4680 in modulating this effect.
| Original language | English |
|---|---|
| Pages (from-to) | 68-72 |
| Number of pages | 5 |
| Journal | Journal of Affective Disorders |
| Volume | 121 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - Feb 2010 |
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Keywords
- Bipolar disorder
- COMT
- Dopamine
- Light therapy
- Major depression
- Norepinephrine
- Sleep deprivation
ASJC Scopus subject areas
- Psychiatry and Mental health
- Clinical Psychology
Cite this
Acute antidepressant response to sleep deprivation combined with light therapy is influenced by the catechol-O-methyltransferase Val(108/158)Met polymorphism. / Benedetti, Francesco; Barbini, Barbara; Bernasconi, Alessandro; Fulgosi, Mara Cigala; Dallaspezia, Sara; Gavinelli, Chiara; Locatelli, Clara; Lorenzi, Cristina; Pirovano, Adele; Radaelli, Daniele; Smeraldi, Enrico; Colombo, Cristina.
In: Journal of Affective Disorders, Vol. 121, No. 1-2, 02.2010, p. 68-72.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Acute antidepressant response to sleep deprivation combined with light therapy is influenced by the catechol-O-methyltransferase Val(108/158)Met polymorphism
AU - Benedetti, Francesco
AU - Barbini, Barbara
AU - Bernasconi, Alessandro
AU - Fulgosi, Mara Cigala
AU - Dallaspezia, Sara
AU - Gavinelli, Chiara
AU - Locatelli, Clara
AU - Lorenzi, Cristina
AU - Pirovano, Adele
AU - Radaelli, Daniele
AU - Smeraldi, Enrico
AU - Colombo, Cristina
PY - 2010/2
Y1 - 2010/2
N2 - Catechol-O-methyltransferase (COMT) inactivates norepinephrine and dopamine via methyl conjugation, and a G-A transition in the COMT gene (rs4680) influences the enzyme activity. It is a current area of debate whether rs4680 can influence antidepressant response in major depressive disorder, and whether this influence extends to bipolar depression. Chronotherapeutic interventions, such as sleep deprivation and light therapy, are multi-target in nature and are effective in bipolar depression. Here we studied the effect of rs4680 on response to sleep deprivation combined with light therapy (36 h awake followed by a night of undisturbed sleep, with 10,000 lx light administered for 30 min during the night awake and upon awakening) in 87 bipolar depressed inpatients. Patients who were homozygotic for the Val/Val variant showed a significantly less efficient antidepressant effect after the night awake than those who were heterozygotic and homozygotic for the Met variant. This effect of rs4680 is similar to its observed influence on response to serotonergic and noradrenergic drug treatments in major depressive disorder. This is the first study reporting an influence of rs4680 on antidepressant response in bipolar depression. This finding supports the hypothesis of a major role for catecholamines in the mechanism of action of chronotherapeutics, and for rs4680 in modulating this effect.
AB - Catechol-O-methyltransferase (COMT) inactivates norepinephrine and dopamine via methyl conjugation, and a G-A transition in the COMT gene (rs4680) influences the enzyme activity. It is a current area of debate whether rs4680 can influence antidepressant response in major depressive disorder, and whether this influence extends to bipolar depression. Chronotherapeutic interventions, such as sleep deprivation and light therapy, are multi-target in nature and are effective in bipolar depression. Here we studied the effect of rs4680 on response to sleep deprivation combined with light therapy (36 h awake followed by a night of undisturbed sleep, with 10,000 lx light administered for 30 min during the night awake and upon awakening) in 87 bipolar depressed inpatients. Patients who were homozygotic for the Val/Val variant showed a significantly less efficient antidepressant effect after the night awake than those who were heterozygotic and homozygotic for the Met variant. This effect of rs4680 is similar to its observed influence on response to serotonergic and noradrenergic drug treatments in major depressive disorder. This is the first study reporting an influence of rs4680 on antidepressant response in bipolar depression. This finding supports the hypothesis of a major role for catecholamines in the mechanism of action of chronotherapeutics, and for rs4680 in modulating this effect.
KW - Bipolar disorder
KW - COMT
KW - Dopamine
KW - Light therapy
KW - Major depression
KW - Norepinephrine
KW - Sleep deprivation
UR - http://www.scopus.com/inward/record.url?scp=72449150176&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=72449150176&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2009.05.017
DO - 10.1016/j.jad.2009.05.017
M3 - Article
C2 - 19520435
AN - SCOPUS:72449150176
VL - 121
SP - 68
EP - 72
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
IS - 1-2
ER -