Protective effects of the antioxidant reduced glutathione and/or the somatostatin analogue octreotide are evaluated in aged rats with acute biliary pancreatitis. A severe pancreatitis involving acinar cells and interstitium determined 100% mortality in 10 untreated rats. Glutathione administration (11 rats) failed to substantially change the histologic features of pancreatitis; nevertheless the antioxidant lowered mortality to 63.6%. Octreotide administration (8 rats) significantly reduced acinar cell pancreatitis and peripancreatic fat necrosis; furthermore the somatostatin long-acting analogue lowered mortality to 37.5%. Combined treatment (8 rats) resulted in reduced histologic effects and higher mortality than those observed with octreotide-only treated animals. Sistemic protection of reduced glutathione suggests that free-radicals production is significant only when severe pancreatitis and subsequent leucocytes activation are already present. Better pancreatic and sistemic protection observed in octreotide-treated rats seems to point out that the somatostatin analogue acts in early steps of acute pancreatitis; mechanism of action still remains circumstantial.
|Translated title of the contribution||Acute biliary pancreatitis in aged rats. Role of reduced glutathione and of octreotide|
|Number of pages||13|
|Journal||Acta Chirurgica Italica|
|Publication status||Published - 1995|
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