AZIONI PROTETTIVE DEL GLUTATIONE RIDOTTO E DELL'OCTREOTIDE NELL'EVOLUZIONE DELLA PANCREATITE ACUTE BILIARE NEL RATTO ANZIANO

Translated title of the contribution: Acute biliary pancreatitis in aged rats. Role of reduced glutathione and of octreotide

R. Nascimbeni, B. Salerni, R. Benassi, G. P. Cengia, L. Lojacono, F. Callea, A. Rodolfi

Research output: Contribution to journalArticle

Abstract

Protective effects of the antioxidant reduced glutathione and/or the somatostatin analogue octreotide are evaluated in aged rats with acute biliary pancreatitis. A severe pancreatitis involving acinar cells and interstitium determined 100% mortality in 10 untreated rats. Glutathione administration (11 rats) failed to substantially change the histologic features of pancreatitis; nevertheless the antioxidant lowered mortality to 63.6%. Octreotide administration (8 rats) significantly reduced acinar cell pancreatitis and peripancreatic fat necrosis; furthermore the somatostatin long-acting analogue lowered mortality to 37.5%. Combined treatment (8 rats) resulted in reduced histologic effects and higher mortality than those observed with octreotide-only treated animals. Sistemic protection of reduced glutathione suggests that free-radicals production is significant only when severe pancreatitis and subsequent leucocytes activation are already present. Better pancreatic and sistemic protection observed in octreotide-treated rats seems to point out that the somatostatin analogue acts in early steps of acute pancreatitis; mechanism of action still remains circumstantial.

Original languageItalian
Pages (from-to)240-252
Number of pages13
JournalActa Chirurgica Italica
Volume51
Issue number3
Publication statusPublished - 1995

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Octreotide
Pancreatitis
Glutathione
Somatostatin
Mortality
Acinar Cells
Antioxidants
Fat Necrosis
Free Radicals
Leukocytes

ASJC Scopus subject areas

  • Surgery

Cite this

Nascimbeni, R., Salerni, B., Benassi, R., Cengia, G. P., Lojacono, L., Callea, F., & Rodolfi, A. (1995). AZIONI PROTETTIVE DEL GLUTATIONE RIDOTTO E DELL'OCTREOTIDE NELL'EVOLUZIONE DELLA PANCREATITE ACUTE BILIARE NEL RATTO ANZIANO. Acta Chirurgica Italica, 51(3), 240-252.

AZIONI PROTETTIVE DEL GLUTATIONE RIDOTTO E DELL'OCTREOTIDE NELL'EVOLUZIONE DELLA PANCREATITE ACUTE BILIARE NEL RATTO ANZIANO. / Nascimbeni, R.; Salerni, B.; Benassi, R.; Cengia, G. P.; Lojacono, L.; Callea, F.; Rodolfi, A.

In: Acta Chirurgica Italica, Vol. 51, No. 3, 1995, p. 240-252.

Research output: Contribution to journalArticle

Nascimbeni, R, Salerni, B, Benassi, R, Cengia, GP, Lojacono, L, Callea, F & Rodolfi, A 1995, 'AZIONI PROTETTIVE DEL GLUTATIONE RIDOTTO E DELL'OCTREOTIDE NELL'EVOLUZIONE DELLA PANCREATITE ACUTE BILIARE NEL RATTO ANZIANO', Acta Chirurgica Italica, vol. 51, no. 3, pp. 240-252.
Nascimbeni, R. ; Salerni, B. ; Benassi, R. ; Cengia, G. P. ; Lojacono, L. ; Callea, F. ; Rodolfi, A. / AZIONI PROTETTIVE DEL GLUTATIONE RIDOTTO E DELL'OCTREOTIDE NELL'EVOLUZIONE DELLA PANCREATITE ACUTE BILIARE NEL RATTO ANZIANO. In: Acta Chirurgica Italica. 1995 ; Vol. 51, No. 3. pp. 240-252.
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