AZIONI PROTETTIVE DEL GLUTATIONE RIDOTTO E DELL'OCTREOTIDE NELL'EVOLUZIONE DELLA PANCREATITE ACUTE BILIARE NEL RATTO ANZIANO

Translated title of the contribution: Acute biliary pancreatitis in aged rats. Role of reduced glutathione and of octreotide

R. Nascimbeni, B. Salerni, R. Benassi, G. P. Cengia, L. Lojacono, F. Callea, A. Rodolfi

Research output: Contribution to journalArticlepeer-review

Abstract

Protective effects of the antioxidant reduced glutathione and/or the somatostatin analogue octreotide are evaluated in aged rats with acute biliary pancreatitis. A severe pancreatitis involving acinar cells and interstitium determined 100% mortality in 10 untreated rats. Glutathione administration (11 rats) failed to substantially change the histologic features of pancreatitis; nevertheless the antioxidant lowered mortality to 63.6%. Octreotide administration (8 rats) significantly reduced acinar cell pancreatitis and peripancreatic fat necrosis; furthermore the somatostatin long-acting analogue lowered mortality to 37.5%. Combined treatment (8 rats) resulted in reduced histologic effects and higher mortality than those observed with octreotide-only treated animals. Sistemic protection of reduced glutathione suggests that free-radicals production is significant only when severe pancreatitis and subsequent leucocytes activation are already present. Better pancreatic and sistemic protection observed in octreotide-treated rats seems to point out that the somatostatin analogue acts in early steps of acute pancreatitis; mechanism of action still remains circumstantial.

Translated title of the contributionAcute biliary pancreatitis in aged rats. Role of reduced glutathione and of octreotide
Original languageItalian
Pages (from-to)240-252
Number of pages13
JournalActa Chirurgica Italica
Volume51
Issue number3
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Surgery

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