Emodiafiltrazione con reinfusione endogena (HFR): profilo di biocompatibilità in acuto.

Translated title of the contribution: Acute biocompatibility of hemodiafiltration with endogenous reinfusion (HFR)

F. Aucella, A. Gesuete, L. Sereni, S. Netti, A. M. Savastano, M. Querques, A. Specchio, A. De Min, C. Avanzi, C. Montemurno, E. Grandone, F. Cappucci, D. A. Procaccini, C. Stallone, L. Gesualdo

Research output: Contribution to journalArticlepeer-review


PURPOSE: In order to reduce the hemodialysis (HD)-induced pro-inflammatory activity we need to use a biocompatible dialysis membrane, avoid backfiltration and possibly use adsorbents. Hemodiafiltration reinfusion (HFR) is a new on-line hemodiafiltration (HDF) technique combining these aspects. This study aimed to evaluate the biocompatibility of the single dialysis session comparing standard HD and HFR. METHODS: Eighteen patients on chronic HD were enrolled in five Centers. Patients underwent one standard and two HFR study sessions; in each session we evaluated leukocyte activation at 0, 5, 15, 60 and 240 min; and interleukin-6 (IL-6), C-reactive protein (CRP) and IL-1 receptor antagonist (IL-1Ra) levels at 0, 60 and 240 min. RESULTS: Leukocyte activation was similar in HD and HFR, while the post-dialysis IL-6 increase was lower with HFR; CRP levels were stable during HFR, but increased after HD, and IL-1Ra did not demonstrate any difference. CONCLUSIONS: These preliminary data show that HFR still has a better biocompatibility in the single dialysis session.

Translated title of the contributionAcute biocompatibility of hemodiafiltration with endogenous reinfusion (HFR)
Original languageItalian
JournalGiornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia
Volume21 Suppl 30
Publication statusPublished - Nov 2004

ASJC Scopus subject areas

  • Nephrology


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