Acute Cellular Rejection Monitoring After Intestinal Transplant: Utility of Serologic Markers and Zoom Videoendoscopy as Support of Conventional Biopsy and Clinical Findings

A. Lauro, A. Altimari, M. Di Simone, A. Dazzi, M. Cescon, C. Zanfi, Z. Miklosova, B. Corti, E. Gruppioni, A. D'Errico, N. Cautero, G. Giustozzi, L. Ansaloni, G. Ramacciato, S. Gruttadauria, G. Gruttadauria, A. D. Pinna

Research output: Contribution to journalArticlepeer-review

Abstract

Acute cellular rejection (ACR) episodes in intestinal transplant recipients are diagnosed by histologic and clinical findings. We have applied zoom video endoscopy and the use of serologic markers granzyme B (GrB) and perforin (PrF) to monitor rejection together with conventional tools. Seven hundred eighty-two blood samples (obtained at the time of the biopsy) collected from 34 recipients for GrB/PrF upregulation were positive among 64.9% of ACRs during a 3-year follow-up. Considering only the first year results posttransplantation, it reached 73.1% of rejection events. Zoom videoendoscopy was used by our group in 29 recipients of isolated intestine (n = 24) or multivisceral transplantations (n = 5) to enable observation of villi and crypt areas. From more than 270 procedures, 84% of the zoom findings agreed with the histologic results, namely, a specificity of 95%. In fact, during ongoing ACR, villi were altered in 80% of cases. Both procedures were helpful to support conventional histologic findings and clinical symptoms of ACR in intestinal transplant recipients.

Original languageEnglish
Pages (from-to)1575-1576
Number of pages2
JournalTransplantation Proceedings
Volume40
Issue number5
DOIs
Publication statusPublished - Jun 2008

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Fingerprint Dive into the research topics of 'Acute Cellular Rejection Monitoring After Intestinal Transplant: Utility of Serologic Markers and Zoom Videoendoscopy as Support of Conventional Biopsy and Clinical Findings'. Together they form a unique fingerprint.

Cite this