Acute cerebellar stroke and middle cerebral artery stroke exert distinctive modifications on functional cortical connectivity

A comparative study via EEG graph theory

Fabrizio Vecchio, Pietro Caliandro, Giuseppe Reale, Francesca Miraglia, Francesca Piludu, Gianvito Masi, Chiara Iacovelli, Chiara Simbolotti, Luca Padua, Edoardo Leone, Francesca Alù, Cesare Colosimo, Paolo Maria Rossini

Research output: Contribution to journalArticle

Abstract

Objective: We tested whether acute cerebellar stroke may determine changes in brain network architecture as defined by cortical sources of EEG rhythms. Methods: Graph parameters of 41 consecutive stroke patients (<5 days from the event) were studied using eLORETA EEG sources. Network rearrangements of stroke patients were investigated in delta, alpha 2, beta 2 and gamma bands in comparison with healthy subjects. Results: The delta network remodeling was similar in cerebellar and middle cerebral artery strokes, with a reduction of small-worldness. Beta 2 and gamma small-worldness, in the right hemisphere of patients with cerebellar stroke, increase respect to healthy subjects, while alpha 2 small-worldness increases only among patients with a middle cerebral artery stroke. Conclusions: The network remodeling characteristics are independent on the size of the ischemic lesion. In the early post-acute stages cerebellar stroke differs from the middle cerebral artery one because it does not cause alpha 2 network remodeling while it determines a high frequency network reorganization in beta 2 and gamma bands with an increase of small-worldness characteristics. Significance: These findings demonstrate changes in the balance of local segregation and global integration induced by cerebellar acute stroke in high EEG frequency bands. They need to be integrated with appropriate follow-up to explore whether further network changes are attained during post-stroke outcome stabilization.

Original languageEnglish
Pages (from-to)997-1007
Number of pages11
JournalClinical Neurophysiology
Volume130
Issue number6
DOIs
Publication statusPublished - Jun 1 2019

Fingerprint

Middle Cerebral Artery Infarction
Electroencephalography
Stroke
Healthy Volunteers
Patient Rights
Brain

Keywords

  • Cerebellum
  • EEG
  • eLORETA
  • Functional connectivity
  • Graph theory
  • Lesion volume
  • MRI
  • Precision medicine
  • Stroke

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Cite this

@article{b45a0a668a444cec93416efe28bc2b99,
title = "Acute cerebellar stroke and middle cerebral artery stroke exert distinctive modifications on functional cortical connectivity: A comparative study via EEG graph theory",
abstract = "Objective: We tested whether acute cerebellar stroke may determine changes in brain network architecture as defined by cortical sources of EEG rhythms. Methods: Graph parameters of 41 consecutive stroke patients (<5 days from the event) were studied using eLORETA EEG sources. Network rearrangements of stroke patients were investigated in delta, alpha 2, beta 2 and gamma bands in comparison with healthy subjects. Results: The delta network remodeling was similar in cerebellar and middle cerebral artery strokes, with a reduction of small-worldness. Beta 2 and gamma small-worldness, in the right hemisphere of patients with cerebellar stroke, increase respect to healthy subjects, while alpha 2 small-worldness increases only among patients with a middle cerebral artery stroke. Conclusions: The network remodeling characteristics are independent on the size of the ischemic lesion. In the early post-acute stages cerebellar stroke differs from the middle cerebral artery one because it does not cause alpha 2 network remodeling while it determines a high frequency network reorganization in beta 2 and gamma bands with an increase of small-worldness characteristics. Significance: These findings demonstrate changes in the balance of local segregation and global integration induced by cerebellar acute stroke in high EEG frequency bands. They need to be integrated with appropriate follow-up to explore whether further network changes are attained during post-stroke outcome stabilization.",
keywords = "Cerebellum, EEG, eLORETA, Functional connectivity, Graph theory, Lesion volume, MRI, Precision medicine, Stroke",
author = "Fabrizio Vecchio and Pietro Caliandro and Giuseppe Reale and Francesca Miraglia and Francesca Piludu and Gianvito Masi and Chiara Iacovelli and Chiara Simbolotti and Luca Padua and Edoardo Leone and Francesca Al{\`u} and Cesare Colosimo and Rossini, {Paolo Maria}",
year = "2019",
month = "6",
day = "1",
doi = "10.1016/j.clinph.2019.03.017",
language = "English",
volume = "130",
pages = "997--1007",
journal = "Clinical Neurophysiology",
issn = "1388-2457",
publisher = "Elsevier Ireland Ltd",
number = "6",

}

TY - JOUR

T1 - Acute cerebellar stroke and middle cerebral artery stroke exert distinctive modifications on functional cortical connectivity

T2 - A comparative study via EEG graph theory

AU - Vecchio, Fabrizio

AU - Caliandro, Pietro

AU - Reale, Giuseppe

AU - Miraglia, Francesca

AU - Piludu, Francesca

AU - Masi, Gianvito

AU - Iacovelli, Chiara

AU - Simbolotti, Chiara

AU - Padua, Luca

AU - Leone, Edoardo

AU - Alù, Francesca

AU - Colosimo, Cesare

AU - Rossini, Paolo Maria

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Objective: We tested whether acute cerebellar stroke may determine changes in brain network architecture as defined by cortical sources of EEG rhythms. Methods: Graph parameters of 41 consecutive stroke patients (<5 days from the event) were studied using eLORETA EEG sources. Network rearrangements of stroke patients were investigated in delta, alpha 2, beta 2 and gamma bands in comparison with healthy subjects. Results: The delta network remodeling was similar in cerebellar and middle cerebral artery strokes, with a reduction of small-worldness. Beta 2 and gamma small-worldness, in the right hemisphere of patients with cerebellar stroke, increase respect to healthy subjects, while alpha 2 small-worldness increases only among patients with a middle cerebral artery stroke. Conclusions: The network remodeling characteristics are independent on the size of the ischemic lesion. In the early post-acute stages cerebellar stroke differs from the middle cerebral artery one because it does not cause alpha 2 network remodeling while it determines a high frequency network reorganization in beta 2 and gamma bands with an increase of small-worldness characteristics. Significance: These findings demonstrate changes in the balance of local segregation and global integration induced by cerebellar acute stroke in high EEG frequency bands. They need to be integrated with appropriate follow-up to explore whether further network changes are attained during post-stroke outcome stabilization.

AB - Objective: We tested whether acute cerebellar stroke may determine changes in brain network architecture as defined by cortical sources of EEG rhythms. Methods: Graph parameters of 41 consecutive stroke patients (<5 days from the event) were studied using eLORETA EEG sources. Network rearrangements of stroke patients were investigated in delta, alpha 2, beta 2 and gamma bands in comparison with healthy subjects. Results: The delta network remodeling was similar in cerebellar and middle cerebral artery strokes, with a reduction of small-worldness. Beta 2 and gamma small-worldness, in the right hemisphere of patients with cerebellar stroke, increase respect to healthy subjects, while alpha 2 small-worldness increases only among patients with a middle cerebral artery stroke. Conclusions: The network remodeling characteristics are independent on the size of the ischemic lesion. In the early post-acute stages cerebellar stroke differs from the middle cerebral artery one because it does not cause alpha 2 network remodeling while it determines a high frequency network reorganization in beta 2 and gamma bands with an increase of small-worldness characteristics. Significance: These findings demonstrate changes in the balance of local segregation and global integration induced by cerebellar acute stroke in high EEG frequency bands. They need to be integrated with appropriate follow-up to explore whether further network changes are attained during post-stroke outcome stabilization.

KW - Cerebellum

KW - EEG

KW - eLORETA

KW - Functional connectivity

KW - Graph theory

KW - Lesion volume

KW - MRI

KW - Precision medicine

KW - Stroke

UR - http://www.scopus.com/inward/record.url?scp=85064321000&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064321000&partnerID=8YFLogxK

U2 - 10.1016/j.clinph.2019.03.017

DO - 10.1016/j.clinph.2019.03.017

M3 - Article

VL - 130

SP - 997

EP - 1007

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

SN - 1388-2457

IS - 6

ER -