Acute changes of blood ammonia may predict short-term adverse effects of valproic acid

Gaetano Zaccara, Roberto Campostrini, Marco Paganini, Flavio Moroni, Tommaso Valenza, Giacomo Targioni, Graziano Arnetoli, Roberto Zappoli, Agostino Baruzzi

Research output: Contribution to journalArticle

Abstract

Valproic acid (VPA) was given to 24 epileptic patients who were already being treated with other antiepileptic drugs. A standardized loading dose of VPA was administered, and venous blood was sampled at 0,1, 2, 3, and 4 hours. Ammonia (NH3) was higher in patients who, during continuous therapy, complained of drowsiness (7 patients) than in those who were symptom-free (17 patients), although VPA plasma levels were similar in both groups. By measuring VPA-induced changes of blood NH3 content, it may he possible to identify patients at higher risk of obtundation when VPA is given chronically.

Original languageEnglish
Pages (from-to)1519-1521
Number of pages3
JournalNeurology
Volume34
Issue number11
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

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    Zaccara, G., Campostrini, R., Paganini, M., Moroni, F., Valenza, T., Targioni, G., Arnetoli, G., Zappoli, R., & Baruzzi, A. (1984). Acute changes of blood ammonia may predict short-term adverse effects of valproic acid. Neurology, 34(11), 1519-1521.