Acute, continuation and maintenance phases of antidepressant treatment

M. C. Mauri, L. S. Volonteri, A. Colasanti, G. Panza

Research output: Contribution to journalArticle

Abstract

Depression is a very prevalent disorder in general population characterized by recurrence and chronicity. The longitudinal studies conducted in the last 30 years described a picture consistent with a long-term illness requiring a life-long maintenance treatment. This paper is a review of the literature on clinical studies about antidepressant treatment, involving the 3 distinct treatment phases: acute, continuation, and maintenance or prophylaxis. The acute phase involves stabilization of acute symptoms and usually lasts 2 to 3 months. The purpose of the continuation phase is to prevent a relapse, and involves continuing medication for an additional 3 or 4 months. The discussed studies underline that an adequate duration of antidepressant therapy is correlated with improvement in symptomatology, the reduction of disabilities, the restoration of functioning and working performance and the prevention of relapse. This results in a substantial improvement in the patient's quality of life and in the achievement of considerable savings in the costs of the disorder. Effective clinical management is often a life-long task. In patients at higher risk for recurrences, prophylactic therapy is recommended, lasting for at least several years.

Original languageEnglish
Pages (from-to)89-98
Number of pages10
JournalMinerva Psichiatrica
Volume46
Issue number2
Publication statusPublished - Jun 2005

Fingerprint

Antidepressive Agents
Maintenance
Recurrence
Therapeutics
Cost Savings
Secondary Prevention
Longitudinal Studies
Quality of Life
Depression
Population

Keywords

  • Antidepressive agents
  • Depressive disorder
  • Prevention of relapse
  • Treatment phases

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Mauri, M. C., Volonteri, L. S., Colasanti, A., & Panza, G. (2005). Acute, continuation and maintenance phases of antidepressant treatment. Minerva Psichiatrica, 46(2), 89-98.

Acute, continuation and maintenance phases of antidepressant treatment. / Mauri, M. C.; Volonteri, L. S.; Colasanti, A.; Panza, G.

In: Minerva Psichiatrica, Vol. 46, No. 2, 06.2005, p. 89-98.

Research output: Contribution to journalArticle

Mauri, MC, Volonteri, LS, Colasanti, A & Panza, G 2005, 'Acute, continuation and maintenance phases of antidepressant treatment', Minerva Psichiatrica, vol. 46, no. 2, pp. 89-98.
Mauri, M. C. ; Volonteri, L. S. ; Colasanti, A. ; Panza, G. / Acute, continuation and maintenance phases of antidepressant treatment. In: Minerva Psichiatrica. 2005 ; Vol. 46, No. 2. pp. 89-98.
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