Acute diffusion abnormalities in the hippocampus of children with new-onset seizures: The development of mesial temporal sclerosis

L. Farina, C. Bergqvist, R. A. Zimmerman, J. Haselgrove, J. V. Hunter, L. T. Bilaniuk

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

We studied the role of early diffusion-weighted imaging DWI in the investigation of children with new-onset prolonged seizures which eventually result in unilateral hippocampal sclerosis (HS). We carried out MRI on five children aged 17 months to 7 years including conventional and diffusion-weighted sequences. We calculated apparent diffusion coefficients (ADC) for the affected and the normal opposite hippocampus. Follow-up examinations were performed, including DWI and ADC measurements in four. We studied four children within 3 days of the onset of prolonged psychomotor seizures and showed increased signal on T2-weighted images, and DWI, indicating restricted diffusion, throughout the affected hippocampus. The ADC were reduced by a mean of 14.4% in the head and by 15% in the body of the hippocampus. In one child examined 15 days after the onset of seizures, the ADC were the same on both sides. All five patients showed hippocampal atrophy on follow-up 2-18 months later. In the four patients in whom ADC were obtained on follow-up, they were increased by 19% in the head and 17% in the body. DWI may represent a useful adjunct to conventional MRI for identifying acute injury to the hippocampus which results in sclerosis.

Original languageEnglish
Pages (from-to)251-257
Number of pages7
JournalNeuroradiology
Volume46
Issue number4
DOIs
Publication statusPublished - Apr 2004

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Sclerosis
Hippocampus
Seizures
Head
Atrophy
Wounds and Injuries

Keywords

  • Childhood
  • Diffusion-weighted imaging
  • Epilepsy
  • Hippocampal slcerosis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Radiological and Ultrasound Technology

Cite this

Acute diffusion abnormalities in the hippocampus of children with new-onset seizures : The development of mesial temporal sclerosis. / Farina, L.; Bergqvist, C.; Zimmerman, R. A.; Haselgrove, J.; Hunter, J. V.; Bilaniuk, L. T.

In: Neuroradiology, Vol. 46, No. 4, 04.2004, p. 251-257.

Research output: Contribution to journalArticle

Farina, L. ; Bergqvist, C. ; Zimmerman, R. A. ; Haselgrove, J. ; Hunter, J. V. ; Bilaniuk, L. T. / Acute diffusion abnormalities in the hippocampus of children with new-onset seizures : The development of mesial temporal sclerosis. In: Neuroradiology. 2004 ; Vol. 46, No. 4. pp. 251-257.
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