Acute effect of high-fat meal on endothelial function in moderately dyslipidemic subjects

C. Giannattasio, A. Zoppo, G. Gentile, M. Failla, A. Capra, F. M. Maggi, A. Catapano, G. Mancia

Research output: Contribution to journalArticlepeer-review


Objective - Hypercholesterolemia markedly impairs endothelial function. Whether this is the case for hypertriglyceridemia is less clear, however, and limited evidence exists on the effect of an acute increase in triglyceridemia caused by a high-fat meal. Methods and Results - In 16 normotensive subjects with an untreated mild hypertriglyceridemia and dyslipidemia and in 7 normal controls, we measured radial artery diameter and blood flow by an echo-tracking device (NIUS02). Data were obtained at baseline, at the release of a 4-minute ischemia of the hand, which causes an increase in arterial diameter dependent on nitric oxide (NO) secretion, and at the release of a 12-minute exclusion of the arm by an arm cuff to obtain a larger increase in arterial diameter mainly of nonendothelial nature. Measurements were performed before and 6 hours after a high-fat meal (680 kcal/m 2 body surface; 82% lipids). In mild dyslipidemic hypertriglyceridemic subjects, the high-fat meal did not alter baseline blood pressure (beat-to-beat finger measurement), heart rate, radial artery diameter, and blood flow. It also did not alter the increase in blood flow induced by the 4-minute ischemia (+42.7±10.4 and +43.7±10.4 mL/min), whereas it markedly attenuated the concomitant increase in arterial diameter (+0.31±0.06 versus 0.13±0.06 mm; P

Original languageEnglish
Pages (from-to)406-410
Number of pages5
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Issue number2
Publication statusPublished - Feb 2005


  • Acute triglyceridemia increase
  • Blood flow
  • Endothelium
  • Triglyceridemia
  • Vasodilation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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