TY - JOUR
T1 - Acute Effect on Satiety, Resting Energy Expenditure, Respiratory Quotient, Glucagon-Like Peptide-1, Free Fatty Acids, and Glycerol Following Consumption of a Combination of Bioactive Food Ingredients in Overweight Subjects
AU - Rondanelli, Mariangela
AU - Opizzi, Annalisa
AU - Perna, Simone
AU - Faliva, Milena
AU - Solerte, Sebastiano Bruno
AU - Fioravanti, Marisa
AU - Klersy, Catherine
AU - Edda, Cava
AU - Maddalena, Paolini
AU - Luciano, Scavone
AU - Paola, Ceccarelli
AU - Emanuela, Castellaneta
AU - Claudia, Savina
AU - Donini, Lorenzo Maria
PY - 2013
Y1 - 2013
N2 - Objective: A combination of bioactive food ingredients (capsaicinoids, epigallocatechin gallate, piperin, and l-carnitine, CBFI) may promote satiety and thermogenesis. The study was conducted in order to assess whether there is any effect on satiety, resting energy expenditure (REE), respiratory quotient, glucagon-like peptide-1 (GLP-1), free fatty acids (FFA) and glycerol release, following a standardized mixed meal with or without single consumption of a CBFI. Design: An 8-week randomized double-blind placebo-controlled trial. Setting: Dietetic and Metabolic Unit, Azienda di Servizi alla Persona, University of Pavia and "Villa delle Querce" Clinical Rehabilitation Institute, Rome, Italy. Participants: Thirty-seven overweight adults (body mass index [BMI]: 25-35). Intervention: Nineteen overweight subjects were included in the supplemented group (14 women, 5 men; age 46.4 ± 6.4; BMI: 30.5 ± 3.3) and 18 in the placebo group (13 women, 5 men; age 40.8 ± 11.5; BMI: 30.1 ± 2.6). Satiety was assessed using 100-mm visual analogue scales (VAS) and the area under the curve was calculated. Results: All measured parameters increased significantly in comparison with baseline in response to meal, both with CBFI and with placebo. However, throughout the study day, the supplemented group experienced a significantly greater increase than the placebo group in their sensation of satiety following acute administration of the supplement. Conclusion: CBFI may therefore be of great value in the treatment of overweight patients by increasing satiety and stimulating thermogenesis.
AB - Objective: A combination of bioactive food ingredients (capsaicinoids, epigallocatechin gallate, piperin, and l-carnitine, CBFI) may promote satiety and thermogenesis. The study was conducted in order to assess whether there is any effect on satiety, resting energy expenditure (REE), respiratory quotient, glucagon-like peptide-1 (GLP-1), free fatty acids (FFA) and glycerol release, following a standardized mixed meal with or without single consumption of a CBFI. Design: An 8-week randomized double-blind placebo-controlled trial. Setting: Dietetic and Metabolic Unit, Azienda di Servizi alla Persona, University of Pavia and "Villa delle Querce" Clinical Rehabilitation Institute, Rome, Italy. Participants: Thirty-seven overweight adults (body mass index [BMI]: 25-35). Intervention: Nineteen overweight subjects were included in the supplemented group (14 women, 5 men; age 46.4 ± 6.4; BMI: 30.5 ± 3.3) and 18 in the placebo group (13 women, 5 men; age 40.8 ± 11.5; BMI: 30.1 ± 2.6). Satiety was assessed using 100-mm visual analogue scales (VAS) and the area under the curve was calculated. Results: All measured parameters increased significantly in comparison with baseline in response to meal, both with CBFI and with placebo. However, throughout the study day, the supplemented group experienced a significantly greater increase than the placebo group in their sensation of satiety following acute administration of the supplement. Conclusion: CBFI may therefore be of great value in the treatment of overweight patients by increasing satiety and stimulating thermogenesis.
KW - capsaicin
KW - carnitine
KW - epigallocatechin gallate
KW - resting energy expenditure
KW - satiety
KW - thermogenesis
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U2 - 10.1080/07315724.2013.767667
DO - 10.1080/07315724.2013.767667
M3 - Article
C2 - 24015698
AN - SCOPUS:84893401158
VL - 32
SP - 41
EP - 49
JO - Journal of the American College of Nutrition
JF - Journal of the American College of Nutrition
SN - 0731-5724
IS - 1
ER -