Acute Effect on Satiety, Resting Energy Expenditure, Respiratory Quotient, Glucagon-Like Peptide-1, Free Fatty Acids, and Glycerol Following Consumption of a Combination of Bioactive Food Ingredients in Overweight Subjects

Mariangela Rondanelli, Annalisa Opizzi, Simone Perna, Milena Faliva, Sebastiano Bruno Solerte, Marisa Fioravanti, Catherine Klersy, Cava Edda, Paolini Maddalena, Scavone Luciano, Ceccarelli Paola, Castellaneta Emanuela, Savina Claudia, Lorenzo Maria Donini

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: A combination of bioactive food ingredients (capsaicinoids, epigallocatechin gallate, piperin, and l-carnitine, CBFI) may promote satiety and thermogenesis. The study was conducted in order to assess whether there is any effect on satiety, resting energy expenditure (REE), respiratory quotient, glucagon-like peptide-1 (GLP-1), free fatty acids (FFA) and glycerol release, following a standardized mixed meal with or without single consumption of a CBFI. Design: An 8-week randomized double-blind placebo-controlled trial. Setting: Dietetic and Metabolic Unit, Azienda di Servizi alla Persona, University of Pavia and "Villa delle Querce" Clinical Rehabilitation Institute, Rome, Italy. Participants: Thirty-seven overweight adults (body mass index [BMI]: 25-35). Intervention: Nineteen overweight subjects were included in the supplemented group (14 women, 5 men; age 46.4 ± 6.4; BMI: 30.5 ± 3.3) and 18 in the placebo group (13 women, 5 men; age 40.8 ± 11.5; BMI: 30.1 ± 2.6). Satiety was assessed using 100-mm visual analogue scales (VAS) and the area under the curve was calculated. Results: All measured parameters increased significantly in comparison with baseline in response to meal, both with CBFI and with placebo. However, throughout the study day, the supplemented group experienced a significantly greater increase than the placebo group in their sensation of satiety following acute administration of the supplement. Conclusion: CBFI may therefore be of great value in the treatment of overweight patients by increasing satiety and stimulating thermogenesis.

Original languageEnglish
Pages (from-to)41-49
Number of pages9
JournalJournal of the American College of Nutrition
Volume32
Issue number1
DOIs
Publication statusPublished - 2013

Fingerprint

Glucagon-Like Peptide 1
Nonesterified Fatty Acids
Glycerol
Energy Metabolism
Placebos
Food
Body Mass Index
Thermogenesis
Meals
Dietetics
Carnitine
Visual Analog Scale
Italy
Area Under Curve
Rehabilitation
Therapeutics

Keywords

  • capsaicin
  • carnitine
  • epigallocatechin gallate
  • resting energy expenditure
  • satiety
  • thermogenesis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Medicine(all)

Cite this

Acute Effect on Satiety, Resting Energy Expenditure, Respiratory Quotient, Glucagon-Like Peptide-1, Free Fatty Acids, and Glycerol Following Consumption of a Combination of Bioactive Food Ingredients in Overweight Subjects. / Rondanelli, Mariangela; Opizzi, Annalisa; Perna, Simone; Faliva, Milena; Solerte, Sebastiano Bruno; Fioravanti, Marisa; Klersy, Catherine; Edda, Cava; Maddalena, Paolini; Luciano, Scavone; Paola, Ceccarelli; Emanuela, Castellaneta; Claudia, Savina; Donini, Lorenzo Maria.

In: Journal of the American College of Nutrition, Vol. 32, No. 1, 2013, p. 41-49.

Research output: Contribution to journalArticle

Rondanelli, Mariangela ; Opizzi, Annalisa ; Perna, Simone ; Faliva, Milena ; Solerte, Sebastiano Bruno ; Fioravanti, Marisa ; Klersy, Catherine ; Edda, Cava ; Maddalena, Paolini ; Luciano, Scavone ; Paola, Ceccarelli ; Emanuela, Castellaneta ; Claudia, Savina ; Donini, Lorenzo Maria. / Acute Effect on Satiety, Resting Energy Expenditure, Respiratory Quotient, Glucagon-Like Peptide-1, Free Fatty Acids, and Glycerol Following Consumption of a Combination of Bioactive Food Ingredients in Overweight Subjects. In: Journal of the American College of Nutrition. 2013 ; Vol. 32, No. 1. pp. 41-49.
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abstract = "Objective: A combination of bioactive food ingredients (capsaicinoids, epigallocatechin gallate, piperin, and l-carnitine, CBFI) may promote satiety and thermogenesis. The study was conducted in order to assess whether there is any effect on satiety, resting energy expenditure (REE), respiratory quotient, glucagon-like peptide-1 (GLP-1), free fatty acids (FFA) and glycerol release, following a standardized mixed meal with or without single consumption of a CBFI. Design: An 8-week randomized double-blind placebo-controlled trial. Setting: Dietetic and Metabolic Unit, Azienda di Servizi alla Persona, University of Pavia and {"}Villa delle Querce{"} Clinical Rehabilitation Institute, Rome, Italy. Participants: Thirty-seven overweight adults (body mass index [BMI]: 25-35). Intervention: Nineteen overweight subjects were included in the supplemented group (14 women, 5 men; age 46.4 ± 6.4; BMI: 30.5 ± 3.3) and 18 in the placebo group (13 women, 5 men; age 40.8 ± 11.5; BMI: 30.1 ± 2.6). Satiety was assessed using 100-mm visual analogue scales (VAS) and the area under the curve was calculated. Results: All measured parameters increased significantly in comparison with baseline in response to meal, both with CBFI and with placebo. However, throughout the study day, the supplemented group experienced a significantly greater increase than the placebo group in their sensation of satiety following acute administration of the supplement. Conclusion: CBFI may therefore be of great value in the treatment of overweight patients by increasing satiety and stimulating thermogenesis.",
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AU - Rondanelli, Mariangela

AU - Opizzi, Annalisa

AU - Perna, Simone

AU - Faliva, Milena

AU - Solerte, Sebastiano Bruno

AU - Fioravanti, Marisa

AU - Klersy, Catherine

AU - Edda, Cava

AU - Maddalena, Paolini

AU - Luciano, Scavone

AU - Paola, Ceccarelli

AU - Emanuela, Castellaneta

AU - Claudia, Savina

AU - Donini, Lorenzo Maria

PY - 2013

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N2 - Objective: A combination of bioactive food ingredients (capsaicinoids, epigallocatechin gallate, piperin, and l-carnitine, CBFI) may promote satiety and thermogenesis. The study was conducted in order to assess whether there is any effect on satiety, resting energy expenditure (REE), respiratory quotient, glucagon-like peptide-1 (GLP-1), free fatty acids (FFA) and glycerol release, following a standardized mixed meal with or without single consumption of a CBFI. Design: An 8-week randomized double-blind placebo-controlled trial. Setting: Dietetic and Metabolic Unit, Azienda di Servizi alla Persona, University of Pavia and "Villa delle Querce" Clinical Rehabilitation Institute, Rome, Italy. Participants: Thirty-seven overweight adults (body mass index [BMI]: 25-35). Intervention: Nineteen overweight subjects were included in the supplemented group (14 women, 5 men; age 46.4 ± 6.4; BMI: 30.5 ± 3.3) and 18 in the placebo group (13 women, 5 men; age 40.8 ± 11.5; BMI: 30.1 ± 2.6). Satiety was assessed using 100-mm visual analogue scales (VAS) and the area under the curve was calculated. Results: All measured parameters increased significantly in comparison with baseline in response to meal, both with CBFI and with placebo. However, throughout the study day, the supplemented group experienced a significantly greater increase than the placebo group in their sensation of satiety following acute administration of the supplement. Conclusion: CBFI may therefore be of great value in the treatment of overweight patients by increasing satiety and stimulating thermogenesis.

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KW - resting energy expenditure

KW - satiety

KW - thermogenesis

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