Acute effects of HMG-CoA reductase inhibitors on biliary lipids in patients with interrupted enterohepatic circulation

M. Muraca, G. Baggio, L. Miconi, M. T. Vilei, S. Martini, C. Gabelli, C. Belluco, M. Lise, G. Crepaldi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

HMG-CoA reductase inhibitors decrease serum cholesterol by inhibiting hepatic cholesterol synthesis, but their influence on biliary lipids is not well characterized. In the present study Pravastatin (80 mg) was administered as a single oral dose to 10 patients with external bile fistula, after 1 week of interruption of the enterohepatic circulation, in order to assess the effect of inhibition of hepatic cholesterol synthesis on biliary lipids in conditions of stimulated bile acid synthesis. Bile was collected every hour for 12 h. On the day before, the same procedure was applied with a placebo, and collected bile used as control. Pravastatin decreased both bile acid and phospholipid concentration to about 60% of basal values; this change was still significant after 10 h. Cholesterol concentration was also decreased to about 70% of basal values, but this change was significant only from the 5th to the 7th h. The per cent of cholic and chenodeoxycholic acid was not affected by the drug, but the ratio of glyco- to tauroconjugated bile acids was decreased to about half the initial values. Bilirubin concentration exhibited a late increase, suggesting a reduction in the bile flow. These results suggest that, in patients with interrupted enterohepatic circulation, biliary excretion of bile acids can be largely dependent on hepatic cholesterol synthesis.

Original languageEnglish
Pages (from-to)204-208
Number of pages5
JournalEuropean Journal of Clinical Investigation
Volume21
Issue number2
Publication statusPublished - 1991

Fingerprint

Enterohepatic Circulation
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Bile Acids and Salts
Bile
Cholesterol
Lipids
Pravastatin
Liver
Cutaneous Fistula
Chenodeoxycholic Acid
Cholic Acid
Bilirubin
Phospholipids
Placebos
Serum
Pharmaceutical Preparations

Keywords

  • biliary bile acids
  • biliary cholesterol
  • biliary phospholipid
  • enterohepatic circulation
  • HMG-CoA reductase inhibitors

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Muraca, M., Baggio, G., Miconi, L., Vilei, M. T., Martini, S., Gabelli, C., ... Crepaldi, G. (1991). Acute effects of HMG-CoA reductase inhibitors on biliary lipids in patients with interrupted enterohepatic circulation. European Journal of Clinical Investigation, 21(2), 204-208.

Acute effects of HMG-CoA reductase inhibitors on biliary lipids in patients with interrupted enterohepatic circulation. / Muraca, M.; Baggio, G.; Miconi, L.; Vilei, M. T.; Martini, S.; Gabelli, C.; Belluco, C.; Lise, M.; Crepaldi, G.

In: European Journal of Clinical Investigation, Vol. 21, No. 2, 1991, p. 204-208.

Research output: Contribution to journalArticle

Muraca, M, Baggio, G, Miconi, L, Vilei, MT, Martini, S, Gabelli, C, Belluco, C, Lise, M & Crepaldi, G 1991, 'Acute effects of HMG-CoA reductase inhibitors on biliary lipids in patients with interrupted enterohepatic circulation', European Journal of Clinical Investigation, vol. 21, no. 2, pp. 204-208.
Muraca, M. ; Baggio, G. ; Miconi, L. ; Vilei, M. T. ; Martini, S. ; Gabelli, C. ; Belluco, C. ; Lise, M. ; Crepaldi, G. / Acute effects of HMG-CoA reductase inhibitors on biliary lipids in patients with interrupted enterohepatic circulation. In: European Journal of Clinical Investigation. 1991 ; Vol. 21, No. 2. pp. 204-208.
@article{0f6088370a9e4558a6b568aeac04fb83,
title = "Acute effects of HMG-CoA reductase inhibitors on biliary lipids in patients with interrupted enterohepatic circulation",
abstract = "HMG-CoA reductase inhibitors decrease serum cholesterol by inhibiting hepatic cholesterol synthesis, but their influence on biliary lipids is not well characterized. In the present study Pravastatin (80 mg) was administered as a single oral dose to 10 patients with external bile fistula, after 1 week of interruption of the enterohepatic circulation, in order to assess the effect of inhibition of hepatic cholesterol synthesis on biliary lipids in conditions of stimulated bile acid synthesis. Bile was collected every hour for 12 h. On the day before, the same procedure was applied with a placebo, and collected bile used as control. Pravastatin decreased both bile acid and phospholipid concentration to about 60{\%} of basal values; this change was still significant after 10 h. Cholesterol concentration was also decreased to about 70{\%} of basal values, but this change was significant only from the 5th to the 7th h. The per cent of cholic and chenodeoxycholic acid was not affected by the drug, but the ratio of glyco- to tauroconjugated bile acids was decreased to about half the initial values. Bilirubin concentration exhibited a late increase, suggesting a reduction in the bile flow. These results suggest that, in patients with interrupted enterohepatic circulation, biliary excretion of bile acids can be largely dependent on hepatic cholesterol synthesis.",
keywords = "biliary bile acids, biliary cholesterol, biliary phospholipid, enterohepatic circulation, HMG-CoA reductase inhibitors",
author = "M. Muraca and G. Baggio and L. Miconi and Vilei, {M. T.} and S. Martini and C. Gabelli and C. Belluco and M. Lise and G. Crepaldi",
year = "1991",
language = "English",
volume = "21",
pages = "204--208",
journal = "European Journal of Clinical Investigation",
issn = "0014-2972",
publisher = "Blackwell Publishing Ltd",
number = "2",

}

TY - JOUR

T1 - Acute effects of HMG-CoA reductase inhibitors on biliary lipids in patients with interrupted enterohepatic circulation

AU - Muraca, M.

AU - Baggio, G.

AU - Miconi, L.

AU - Vilei, M. T.

AU - Martini, S.

AU - Gabelli, C.

AU - Belluco, C.

AU - Lise, M.

AU - Crepaldi, G.

PY - 1991

Y1 - 1991

N2 - HMG-CoA reductase inhibitors decrease serum cholesterol by inhibiting hepatic cholesterol synthesis, but their influence on biliary lipids is not well characterized. In the present study Pravastatin (80 mg) was administered as a single oral dose to 10 patients with external bile fistula, after 1 week of interruption of the enterohepatic circulation, in order to assess the effect of inhibition of hepatic cholesterol synthesis on biliary lipids in conditions of stimulated bile acid synthesis. Bile was collected every hour for 12 h. On the day before, the same procedure was applied with a placebo, and collected bile used as control. Pravastatin decreased both bile acid and phospholipid concentration to about 60% of basal values; this change was still significant after 10 h. Cholesterol concentration was also decreased to about 70% of basal values, but this change was significant only from the 5th to the 7th h. The per cent of cholic and chenodeoxycholic acid was not affected by the drug, but the ratio of glyco- to tauroconjugated bile acids was decreased to about half the initial values. Bilirubin concentration exhibited a late increase, suggesting a reduction in the bile flow. These results suggest that, in patients with interrupted enterohepatic circulation, biliary excretion of bile acids can be largely dependent on hepatic cholesterol synthesis.

AB - HMG-CoA reductase inhibitors decrease serum cholesterol by inhibiting hepatic cholesterol synthesis, but their influence on biliary lipids is not well characterized. In the present study Pravastatin (80 mg) was administered as a single oral dose to 10 patients with external bile fistula, after 1 week of interruption of the enterohepatic circulation, in order to assess the effect of inhibition of hepatic cholesterol synthesis on biliary lipids in conditions of stimulated bile acid synthesis. Bile was collected every hour for 12 h. On the day before, the same procedure was applied with a placebo, and collected bile used as control. Pravastatin decreased both bile acid and phospholipid concentration to about 60% of basal values; this change was still significant after 10 h. Cholesterol concentration was also decreased to about 70% of basal values, but this change was significant only from the 5th to the 7th h. The per cent of cholic and chenodeoxycholic acid was not affected by the drug, but the ratio of glyco- to tauroconjugated bile acids was decreased to about half the initial values. Bilirubin concentration exhibited a late increase, suggesting a reduction in the bile flow. These results suggest that, in patients with interrupted enterohepatic circulation, biliary excretion of bile acids can be largely dependent on hepatic cholesterol synthesis.

KW - biliary bile acids

KW - biliary cholesterol

KW - biliary phospholipid

KW - enterohepatic circulation

KW - HMG-CoA reductase inhibitors

UR - http://www.scopus.com/inward/record.url?scp=0025730256&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025730256&partnerID=8YFLogxK

M3 - Article

VL - 21

SP - 204

EP - 208

JO - European Journal of Clinical Investigation

JF - European Journal of Clinical Investigation

SN - 0014-2972

IS - 2

ER -