Abstract
We tested whether dispersible L-dopa has acute effects on event-related desynchronization (ERD) of the mu rhythm in patients with idiopathic Parkinson's disease (IPD). ERD to voluntary movement is delayed in akinetic IPD patients and improves after chronic L-dopa treatment. We evaluated ERD to self-paced finger movement in 14 IPD patients (before and 30-40 min after oral administration of dispersible L-dopa) and in 10 normal subjects. Sensorimotor ERD onset contralateral to movement was significantly delayed in IPD patients compared to normal subjects. This abnormality was no longer significant after L-dopa treatment. We conclude that a single dose of dispersible L-dopa can improve not only motor performance in IPD patients but also the timing of cortical activation of sensorimotor areas during motor programming.
Original language | English |
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Pages (from-to) | 91-97 |
Number of pages | 7 |
Journal | Neurological Sciences |
Volume | 23 |
Issue number | 3 |
DOIs | |
Publication status | Published - Sep 2002 |
Keywords
- Event-related desynchronization
- L-dopa
- Parkinson's disease
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Neurology