Acute effects of L-dopa on event-related desynchronization in Parkinson's disease

G. Magnani, M. Cursi, L. Leocani, M. A. Volonté, G. Comi

Research output: Contribution to journalArticlepeer-review


We tested whether dispersible L-dopa has acute effects on event-related desynchronization (ERD) of the mu rhythm in patients with idiopathic Parkinson's disease (IPD). ERD to voluntary movement is delayed in akinetic IPD patients and improves after chronic L-dopa treatment. We evaluated ERD to self-paced finger movement in 14 IPD patients (before and 30-40 min after oral administration of dispersible L-dopa) and in 10 normal subjects. Sensorimotor ERD onset contralateral to movement was significantly delayed in IPD patients compared to normal subjects. This abnormality was no longer significant after L-dopa treatment. We conclude that a single dose of dispersible L-dopa can improve not only motor performance in IPD patients but also the timing of cortical activation of sensorimotor areas during motor programming.

Original languageEnglish
Pages (from-to)91-97
Number of pages7
JournalNeurological Sciences
Issue number3
Publication statusPublished - Sep 2002


  • Event-related desynchronization
  • L-dopa
  • Parkinson's disease

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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