Abstract
We tested whether dispersible L-dopa has acute effects on event-related desynchronization (ERD) of the mu rhythm in patients with idiopathic Parkinson's disease (IPD). ERD to voluntary movement is delayed in akinetic IPD patients and improves after chronic L-dopa treatment. We evaluated ERD to self-paced finger movement in 14 IPD patients (before and 30-40 min after oral administration of dispersible L-dopa) and in 10 normal subjects. Sensorimotor ERD onset contralateral to movement was significantly delayed in IPD patients compared to normal subjects. This abnormality was no longer significant after L-dopa treatment. We conclude that a single dose of dispersible L-dopa can improve not only motor performance in IPD patients but also the timing of cortical activation of sensorimotor areas during motor programming.
| Original language | English |
|---|---|
| Pages (from-to) | 91-97 |
| Number of pages | 7 |
| Journal | Neurological Sciences |
| Volume | 23 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sep 2002 |
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Keywords
- Event-related desynchronization
- L-dopa
- Parkinson's disease
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Neurology
Cite this
Acute effects of L-dopa on event-related desynchronization in Parkinson's disease. / Magnani, G.; Cursi, M.; Leocani, L.; Volonté, M. A.; Comi, G.
In: Neurological Sciences, Vol. 23, No. 3, 09.2002, p. 91-97.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Acute effects of L-dopa on event-related desynchronization in Parkinson's disease
AU - Magnani, G.
AU - Cursi, M.
AU - Leocani, L.
AU - Volonté, M. A.
AU - Comi, G.
PY - 2002/9
Y1 - 2002/9
N2 - We tested whether dispersible L-dopa has acute effects on event-related desynchronization (ERD) of the mu rhythm in patients with idiopathic Parkinson's disease (IPD). ERD to voluntary movement is delayed in akinetic IPD patients and improves after chronic L-dopa treatment. We evaluated ERD to self-paced finger movement in 14 IPD patients (before and 30-40 min after oral administration of dispersible L-dopa) and in 10 normal subjects. Sensorimotor ERD onset contralateral to movement was significantly delayed in IPD patients compared to normal subjects. This abnormality was no longer significant after L-dopa treatment. We conclude that a single dose of dispersible L-dopa can improve not only motor performance in IPD patients but also the timing of cortical activation of sensorimotor areas during motor programming.
AB - We tested whether dispersible L-dopa has acute effects on event-related desynchronization (ERD) of the mu rhythm in patients with idiopathic Parkinson's disease (IPD). ERD to voluntary movement is delayed in akinetic IPD patients and improves after chronic L-dopa treatment. We evaluated ERD to self-paced finger movement in 14 IPD patients (before and 30-40 min after oral administration of dispersible L-dopa) and in 10 normal subjects. Sensorimotor ERD onset contralateral to movement was significantly delayed in IPD patients compared to normal subjects. This abnormality was no longer significant after L-dopa treatment. We conclude that a single dose of dispersible L-dopa can improve not only motor performance in IPD patients but also the timing of cortical activation of sensorimotor areas during motor programming.
KW - Event-related desynchronization
KW - L-dopa
KW - Parkinson's disease
UR - http://www.scopus.com/inward/record.url?scp=0036755626&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036755626&partnerID=8YFLogxK
U2 - 10.1007/s100720200033
DO - 10.1007/s100720200033
M3 - Article
C2 - 12391492
AN - SCOPUS:0036755626
VL - 23
SP - 91
EP - 97
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 3
ER -