Acute effects of long-acting nicardipine and enalapril on the quality of life in elderly patients

A. Scuteri, M. Cacciafesta, C. R. Bellucci, A. M. De Propris, M. G. Di Bernardo, G. Piccirillo, R. Capuano, A. Ariani, V. Marigliano

Research output: Contribution to journalArticlepeer-review

Abstract

Hypertension is often associated with cognitive deterioration and impaired activities of daily living. A good antihypertensive drug not only has to lower blood pressure but also must improve the mental functioning of elderly patients without increasing other cardiovascular risk factors. Two groups of 15 elderly hypertensive patients were treated with long-acting nicardipine or enalapril. The two treated groups showed a significant decrease in blood pressure values, while no changes were found in the placebo control group. The two treated groups also exhibited a significant (P <0.001) improvement in cognitive functioning and activities of daily living, as assessed by the Mini-Mental State Examination, Geriatric Rating Scale, and Sandoz Clinical Assessment Geriatric Scale. Long-acting nicardipine and enalapril appear to be effective in lowering blood pressure and improving the mental functions of elderly hypertensive patients.

Original languageEnglish
Pages (from-to)773-778
Number of pages6
JournalCurrent Therapeutic Research
Volume51
Issue number5
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Medicine(all)

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