Acute effects of long-acting nicardipine and enalapril on the quality of life in elderly patients

A. Scuteri; M. Cacciafesta; C. R. Bellucci; A. M. De Propris; M. G. Di Bernardo; G. Piccirillo; R. Capuano; A. Ariani; V. Marigliano

Acute effects of long-acting nicardipine and enalapril on the quality of life in elderly patients

A. Scuteri, M. Cacciafesta, C. R. Bellucci, A. M. De Propris, M. G. Di Bernardo, G. Piccirillo, R. Capuano, A. Ariani, V. Marigliano

Istituto San Raffaele Pisana

Research output: Contribution to journal › Article › peer-review

Abstract

Hypertension is often associated with cognitive deterioration and impaired activities of daily living. A good antihypertensive drug not only has to lower blood pressure but also must improve the mental functioning of elderly patients without increasing other cardiovascular risk factors. Two groups of 15 elderly hypertensive patients were treated with long-acting nicardipine or enalapril. The two treated groups showed a significant decrease in blood pressure values, while no changes were found in the placebo control group. The two treated groups also exhibited a significant (P <0.001) improvement in cognitive functioning and activities of daily living, as assessed by the Mini-Mental State Examination, Geriatric Rating Scale, and Sandoz Clinical Assessment Geriatric Scale. Long-acting nicardipine and enalapril appear to be effective in lowering blood pressure and improving the mental functions of elderly hypertensive patients.

Original language	English
Pages (from-to)	773-778
Number of pages	6
Journal	Current Therapeutic Research
Volume	51
Issue number	5
Publication status	Published - 1992

ASJC Scopus subject areas

Medicine(all)

Cite this

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title = "Acute effects of long-acting nicardipine and enalapril on the quality of life in elderly patients",

abstract = "Hypertension is often associated with cognitive deterioration and impaired activities of daily living. A good antihypertensive drug not only has to lower blood pressure but also must improve the mental functioning of elderly patients without increasing other cardiovascular risk factors. Two groups of 15 elderly hypertensive patients were treated with long-acting nicardipine or enalapril. The two treated groups showed a significant decrease in blood pressure values, while no changes were found in the placebo control group. The two treated groups also exhibited a significant (P <0.001) improvement in cognitive functioning and activities of daily living, as assessed by the Mini-Mental State Examination, Geriatric Rating Scale, and Sandoz Clinical Assessment Geriatric Scale. Long-acting nicardipine and enalapril appear to be effective in lowering blood pressure and improving the mental functions of elderly hypertensive patients.",

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T1 - Acute effects of long-acting nicardipine and enalapril on the quality of life in elderly patients

AU - Scuteri, A.

AU - Cacciafesta, M.

AU - Bellucci, C. R.

AU - De Propris, A. M.

AU - Di Bernardo, M. G.

AU - Piccirillo, G.

AU - Capuano, R.

AU - Ariani, A.

AU - Marigliano, V.

PY - 1992

Y1 - 1992

N2 - Hypertension is often associated with cognitive deterioration and impaired activities of daily living. A good antihypertensive drug not only has to lower blood pressure but also must improve the mental functioning of elderly patients without increasing other cardiovascular risk factors. Two groups of 15 elderly hypertensive patients were treated with long-acting nicardipine or enalapril. The two treated groups showed a significant decrease in blood pressure values, while no changes were found in the placebo control group. The two treated groups also exhibited a significant (P <0.001) improvement in cognitive functioning and activities of daily living, as assessed by the Mini-Mental State Examination, Geriatric Rating Scale, and Sandoz Clinical Assessment Geriatric Scale. Long-acting nicardipine and enalapril appear to be effective in lowering blood pressure and improving the mental functions of elderly hypertensive patients.

AB - Hypertension is often associated with cognitive deterioration and impaired activities of daily living. A good antihypertensive drug not only has to lower blood pressure but also must improve the mental functioning of elderly patients without increasing other cardiovascular risk factors. Two groups of 15 elderly hypertensive patients were treated with long-acting nicardipine or enalapril. The two treated groups showed a significant decrease in blood pressure values, while no changes were found in the placebo control group. The two treated groups also exhibited a significant (P <0.001) improvement in cognitive functioning and activities of daily living, as assessed by the Mini-Mental State Examination, Geriatric Rating Scale, and Sandoz Clinical Assessment Geriatric Scale. Long-acting nicardipine and enalapril appear to be effective in lowering blood pressure and improving the mental functions of elderly hypertensive patients.

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Acute effects of long-acting nicardipine and enalapril on the quality of life in elderly patients

Abstract

ASJC Scopus subject areas

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