Abstract
We studied the short-term effects of oral administration of nisoldipine (10 mg) and propranolol (80 mg) alone and in combination in 14 patients with chronic exertional angina pectoris in a double-blind, randomized, cross-over study. The 14 patients (13 men and 1 woman, mean age 56 ± 7 years) performed symptoms-limited bicycle exercise stress test 3 h after placebo or active substance administration. Maximal work load, exercise duration, and time to 1-mm ST segment depression were significantly increased and ST depression at peak exercise was significantly decreased by drugs alone and in combination. Propranolol and nisoldipine alone improved exercise duration similarly and as well as the combination; however, a different response to the three pharmacologic interventions was found in patients treated with single drugs. The improvement in exercise tolerance was associated with rate-pressure product values at peak exercise, unchanged after nisoldipine and significantly reduced after both propranolol alone and in combination. After placebo, all patients had exercise-induced angina, in 9, 8, and 4 patients after nisoldipine, propranolol, and the combination of the two drugs, respectively. Nisoldipine is effective in the treatment of effort angina and its combination with propranolol may be useful and superior in patients who show poor response to monotherapy.
| Original language | English |
|---|---|
| Pages (from-to) | 325-330 |
| Number of pages | 6 |
| Journal | Journal of Cardiovascular Pharmacology |
| Volume | 16 |
| Issue number | 2 |
| Publication status | Published - 1990 |
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Keywords
- Coronary artery disease
- Exercise stress test
- Nisoldipine
- Propranolol
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Pharmacology
Cite this
Acute effects of nisoldipine, propranolol, and their combination in patients with chronic stable angina : A double-blind, randomized, cross-over, placebo-controlled study. / De Caprio, Lorenzo; Papa, Marco; Acanfora, Domenico; Abete, Pasquale; Gallucci, Fernando; Covelluzzi, Filomeno; Michele Cicatiello, A.; Rengo, Franco.
In: Journal of Cardiovascular Pharmacology, Vol. 16, No. 2, 1990, p. 325-330.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Acute effects of nisoldipine, propranolol, and their combination in patients with chronic stable angina
T2 - A double-blind, randomized, cross-over, placebo-controlled study
AU - De Caprio, Lorenzo
AU - Papa, Marco
AU - Acanfora, Domenico
AU - Abete, Pasquale
AU - Gallucci, Fernando
AU - Covelluzzi, Filomeno
AU - Michele Cicatiello, A.
AU - Rengo, Franco
PY - 1990
Y1 - 1990
N2 - We studied the short-term effects of oral administration of nisoldipine (10 mg) and propranolol (80 mg) alone and in combination in 14 patients with chronic exertional angina pectoris in a double-blind, randomized, cross-over study. The 14 patients (13 men and 1 woman, mean age 56 ± 7 years) performed symptoms-limited bicycle exercise stress test 3 h after placebo or active substance administration. Maximal work load, exercise duration, and time to 1-mm ST segment depression were significantly increased and ST depression at peak exercise was significantly decreased by drugs alone and in combination. Propranolol and nisoldipine alone improved exercise duration similarly and as well as the combination; however, a different response to the three pharmacologic interventions was found in patients treated with single drugs. The improvement in exercise tolerance was associated with rate-pressure product values at peak exercise, unchanged after nisoldipine and significantly reduced after both propranolol alone and in combination. After placebo, all patients had exercise-induced angina, in 9, 8, and 4 patients after nisoldipine, propranolol, and the combination of the two drugs, respectively. Nisoldipine is effective in the treatment of effort angina and its combination with propranolol may be useful and superior in patients who show poor response to monotherapy.
AB - We studied the short-term effects of oral administration of nisoldipine (10 mg) and propranolol (80 mg) alone and in combination in 14 patients with chronic exertional angina pectoris in a double-blind, randomized, cross-over study. The 14 patients (13 men and 1 woman, mean age 56 ± 7 years) performed symptoms-limited bicycle exercise stress test 3 h after placebo or active substance administration. Maximal work load, exercise duration, and time to 1-mm ST segment depression were significantly increased and ST depression at peak exercise was significantly decreased by drugs alone and in combination. Propranolol and nisoldipine alone improved exercise duration similarly and as well as the combination; however, a different response to the three pharmacologic interventions was found in patients treated with single drugs. The improvement in exercise tolerance was associated with rate-pressure product values at peak exercise, unchanged after nisoldipine and significantly reduced after both propranolol alone and in combination. After placebo, all patients had exercise-induced angina, in 9, 8, and 4 patients after nisoldipine, propranolol, and the combination of the two drugs, respectively. Nisoldipine is effective in the treatment of effort angina and its combination with propranolol may be useful and superior in patients who show poor response to monotherapy.
KW - Coronary artery disease
KW - Exercise stress test
KW - Nisoldipine
KW - Propranolol
UR - http://www.scopus.com/inward/record.url?scp=0025346708&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025346708&partnerID=8YFLogxK
M3 - Article
C2 - 1697390
AN - SCOPUS:0025346708
VL - 16
SP - 325
EP - 330
JO - Journal of Cardiovascular Pharmacology
JF - Journal of Cardiovascular Pharmacology
SN - 0160-2446
IS - 2
ER -