Acute effects of nisoldipine, propranolol, and their combination in patients with chronic stable angina: A double-blind, randomized, cross-over, placebo-controlled study

Lorenzo De Caprio, Marco Papa, Domenico Acanfora, Pasquale Abete, Fernando Gallucci, Filomeno Covelluzzi, A. Michele Cicatiello, Franco Rengo

Research output: Contribution to journalArticlepeer-review

Abstract

We studied the short-term effects of oral administration of nisoldipine (10 mg) and propranolol (80 mg) alone and in combination in 14 patients with chronic exertional angina pectoris in a double-blind, randomized, cross-over study. The 14 patients (13 men and 1 woman, mean age 56 ± 7 years) performed symptoms-limited bicycle exercise stress test 3 h after placebo or active substance administration. Maximal work load, exercise duration, and time to 1-mm ST segment depression were significantly increased and ST depression at peak exercise was significantly decreased by drugs alone and in combination. Propranolol and nisoldipine alone improved exercise duration similarly and as well as the combination; however, a different response to the three pharmacologic interventions was found in patients treated with single drugs. The improvement in exercise tolerance was associated with rate-pressure product values at peak exercise, unchanged after nisoldipine and significantly reduced after both propranolol alone and in combination. After placebo, all patients had exercise-induced angina, in 9, 8, and 4 patients after nisoldipine, propranolol, and the combination of the two drugs, respectively. Nisoldipine is effective in the treatment of effort angina and its combination with propranolol may be useful and superior in patients who show poor response to monotherapy.

Original languageEnglish
Pages (from-to)325-330
Number of pages6
JournalJournal of Cardiovascular Pharmacology
Volume16
Issue number2
Publication statusPublished - 1990

Keywords

  • Coronary artery disease
  • Exercise stress test
  • Nisoldipine
  • Propranolol

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

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