Abstract
Background: Sublingual nitrates are much more effective in relieving angina pectoris in patients with coronary artery disease than in patients with syndrome X, but it is not known whether their effect on exercise tolerance is also different in these two groups of patients. Methods and Results: Treadmill exercise testing was performed before and after administration of sublingual isosorbide dinitrate (ISDN, 5 mg) in 18 patients with syndrome X (effort angina and normal coronaries, group X) and in 33 patients with documented coronary artery disease (group C). As a selection criterion, all patients had ST-segment depression ≥1 mm on the control exercise test. Compared with the control test, the main differences in the two groups observed during the exercise test after administration of ISDN were (1) heart rate at 1-mm ST-segment depression was higher (126±25 versus 104±15 beats per minute [bpm], P
| Original language | English |
|---|---|
| Pages (from-to) | 2695-2700 |
| Number of pages | 6 |
| Journal | Circulation |
| Volume | 90 |
| Issue number | 6 |
| Publication status | Published - Dec 1994 |
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Keywords
- exercise
- nitrates
- syndrome X
- tests
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine
Cite this
Acute effects of nitrates on exercise testing in patients with syndrome X : Clinical and pathophysiological implications. / Lanza, Gaetano Antonio; Manzoli, Alessandro; Bia, Elena; Crea, Filippo; Maseri, Attilio.
In: Circulation, Vol. 90, No. 6, 12.1994, p. 2695-2700.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Acute effects of nitrates on exercise testing in patients with syndrome X
T2 - Clinical and pathophysiological implications
AU - Lanza, Gaetano Antonio
AU - Manzoli, Alessandro
AU - Bia, Elena
AU - Crea, Filippo
AU - Maseri, Attilio
PY - 1994/12
Y1 - 1994/12
N2 - Background: Sublingual nitrates are much more effective in relieving angina pectoris in patients with coronary artery disease than in patients with syndrome X, but it is not known whether their effect on exercise tolerance is also different in these two groups of patients. Methods and Results: Treadmill exercise testing was performed before and after administration of sublingual isosorbide dinitrate (ISDN, 5 mg) in 18 patients with syndrome X (effort angina and normal coronaries, group X) and in 33 patients with documented coronary artery disease (group C). As a selection criterion, all patients had ST-segment depression ≥1 mm on the control exercise test. Compared with the control test, the main differences in the two groups observed during the exercise test after administration of ISDN were (1) heart rate at 1-mm ST-segment depression was higher (126±25 versus 104±15 beats per minute [bpm], P
AB - Background: Sublingual nitrates are much more effective in relieving angina pectoris in patients with coronary artery disease than in patients with syndrome X, but it is not known whether their effect on exercise tolerance is also different in these two groups of patients. Methods and Results: Treadmill exercise testing was performed before and after administration of sublingual isosorbide dinitrate (ISDN, 5 mg) in 18 patients with syndrome X (effort angina and normal coronaries, group X) and in 33 patients with documented coronary artery disease (group C). As a selection criterion, all patients had ST-segment depression ≥1 mm on the control exercise test. Compared with the control test, the main differences in the two groups observed during the exercise test after administration of ISDN were (1) heart rate at 1-mm ST-segment depression was higher (126±25 versus 104±15 beats per minute [bpm], P
KW - exercise
KW - nitrates
KW - syndrome X
KW - tests
UR - http://www.scopus.com/inward/record.url?scp=0028625448&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028625448&partnerID=8YFLogxK
M3 - Article
C2 - 7994810
AN - SCOPUS:0028625448
VL - 90
SP - 2695
EP - 2700
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 6
ER -