Acute effects of nitrates on exercise testing in patients with syndrome X: Clinical and pathophysiological implications

Gaetano Antonio Lanza, Alessandro Manzoli, Elena Bia, Filippo Crea, Attilio Maseri

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Sublingual nitrates are much more effective in relieving angina pectoris in patients with coronary artery disease than in patients with syndrome X, but it is not known whether their effect on exercise tolerance is also different in these two groups of patients. Methods and Results: Treadmill exercise testing was performed before and after administration of sublingual isosorbide dinitrate (ISDN, 5 mg) in 18 patients with syndrome X (effort angina and normal coronaries, group X) and in 33 patients with documented coronary artery disease (group C). As a selection criterion, all patients had ST-segment depression ≥1 mm on the control exercise test. Compared with the control test, the main differences in the two groups observed during the exercise test after administration of ISDN were (1) heart rate at 1-mm ST-segment depression was higher (126±25 versus 104±15 beats per minute [bpm], P

Original languageEnglish
Pages (from-to)2695-2700
Number of pages6
JournalCirculation
Volume90
Issue number6
Publication statusPublished - Dec 1994

Keywords

  • exercise
  • nitrates
  • syndrome X
  • tests

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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