Acute effects of positive end-expiratory pressure on left ventricle diastolic function in healthy subjects

Alberto Maestroni, Stefano Aliberti, Omar Amir, Giuseppe Milani, Anna Maria Brambilla, Federico Piffer, Francesca Tardini, Roberto Cosentini

Research output: Contribution to journalArticle

Abstract

We evaluated the acute effect of the application of positive end-expiratory pressure (PEEP) on LV diastolic function in 10 healthy subjects. We assessed load dependent diastolic function by Doppler examination of transmitral flow and load independent diastolic function by color M-mode propagation velocity of early flow into the LV cavity (Vp). During the application of PEEP in comparison to the baseline, we found a significant reduction of the E wave peak velocity [79 (64-83) vs. 65 (57-72) cm/s; p = 0.028] and a significant reduction in Vp [84 (73-97) vs. 53 (48-66); p = 0.012]. Moreover, we found a significant reduction in left atrial area [15 (13-18) vs. 12 (10-14) cm2; p = 0.018] and right atrial area [12 (11-15) vs. 11 (9-12) cm2; p = 0.015]. No difference was found in global LV systolic function. The application of PEEP acutely modifies the diastolic flow pattern across the mitral valve, and reduces atrial dimensions.

Original languageEnglish
Pages (from-to)249-254
Number of pages6
JournalInternal and Emergency Medicine
Volume4
Issue number3
DOIs
Publication statusPublished - Jun 2009

Keywords

  • Cardiopulmonary interactions
  • Cardiovascular imaging
  • Non-invasive mechanical ventilation
  • Positive end-expiratory pressure

ASJC Scopus subject areas

  • Emergency Medicine
  • Internal Medicine

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