The immediate effects of smoking on the cerebral circulation was investigated in healthy subjects, smokers and nonsmokers, by means of the 2 cigarette test of Kaufmann, with simultaneous rheo encephalo ophthalmodynamographic control. The investigations were carried out on 20 healthy subjects, (17 male and 3 female), aged between 21 and 38 yr old), in whom there were no demonstrable signs of cardiovascular disease. The recordings were taken with the patients in the semi recumbent position, (70°), before and immediately after smoking 2 cigarettes, and again after a further 10 min. Comparison of the REG readings showed that immediately following the cigarette there was a distinct distict drop in the bihemispheric pulse volume and ophthalmic pulse volume, but a rise in pulse rate more marked in the nonsmokers, and a rise in systolic and diastolic pressure both in the arm and in the eye. After 10 min there was a persistent fall in the bihemispheric and ophthalmic pulse volume, with a further slowing of the pulse rate among the smokers (rebound phenomenon). The same variation was found among smokers and nonsmokers alike in the systolic and diastolic blood pressures, humeral and ophthalmic. In the light of different hemodynamic changes observed in the 3 groups of subjects, it is suggested that there is, among smokers, apart from the diminished vascular elasticity associated with chronic damage caused by smoking, a predominance of sympathetic tone and different rates of absorption of nicotine.
|Number of pages||8|
|Publication status||Published - 1973|
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