Acute effects of the use of estrogens in association with progestogens on postprandial triglyceridemia and vascular reactivity.

S. C. Santos, Jaime Augusto Canashiro, O. C. Gebara, José Mendes Aldrighi, Nubia Vieira, Amit Nussbacher, Humberto Pierri, João Serro-Azul, Maurício Wajngarten, Giuseppe Rosano, J. A. Ramires

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To assess whether hormone replacement therapy with estrogens in association with progestogens in postmenopausal hypertensive women alters postprandial triglyceridemia and vascular reactivity. METHODS: A double-blind, placebo-controlled, crossover study was carried out with 15 postmenopausal women (age range: 50 to 70 years, mean = 61.6 +/- 6 years) randomly assigned to 2 weeks of placebo or oral ingestion of 0.625 mg of equine conjugated estrogens and 2.5 mg of medroxyprogesterone, fed a high-fat diet (897 calories; 50.1% fat). Vascular reactivity (VR - % of vessel diameter variation in the fasting period and 2 hours after meals) was measured by using the automated ultrasound method. Lipid profile and glycemia during the fasting period and 2 hours after a high-fat meal were measured. RESULTS: With placebo, vascular reactivity (VR) decreased from 3.20 +/- 17% during the fasting period to -2.1 +/- 30% 2 hours after the meal (P = 0.041). With the hormone replacement therapy, vascular reactivity decreased from 6.14 +/- 27% during the fasting period to - 0.05 +/- 18% 2 hours after the meal (P = NS). Postprandial triglyceridemia increased as follows: 35 +/- 25% with placebo; and 12 +/- 10% with hormone replacement therapy (P <0.05). CONCLUSION: In postmenopausal hypertensive women, 2 weeks of hormone replacement with an association of estrogens and progestogens decreased hypertriglyceridemia after a high-fat meal, an effect that may reduce the endothelial dysfunction occurring in the postprandial period.

Original languageEnglish
JournalArquivos Brasileiros de Cardiologia
Volume83
Issue number5
Publication statusPublished - Nov 2004

Fingerprint

Progestins
Blood Vessels
Meals
Estrogens
Fasting
Hormone Replacement Therapy
Placebos
Fats
Medroxyprogesterone
Postprandial Period
Conjugated (USP) Estrogens
Hypertriglyceridemia
High Fat Diet
Cross-Over Studies
Eating
Hormones
Lipids

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Santos, S. C., Canashiro, J. A., Gebara, O. C., Aldrighi, J. M., Vieira, N., Nussbacher, A., ... Ramires, J. A. (2004). Acute effects of the use of estrogens in association with progestogens on postprandial triglyceridemia and vascular reactivity. Arquivos Brasileiros de Cardiologia, 83(5).

Acute effects of the use of estrogens in association with progestogens on postprandial triglyceridemia and vascular reactivity. / Santos, S. C.; Canashiro, Jaime Augusto; Gebara, O. C.; Aldrighi, José Mendes; Vieira, Nubia; Nussbacher, Amit; Pierri, Humberto; Serro-Azul, João; Wajngarten, Maurício; Rosano, Giuseppe; Ramires, J. A.

In: Arquivos Brasileiros de Cardiologia, Vol. 83, No. 5, 11.2004.

Research output: Contribution to journalArticle

Santos, SC, Canashiro, JA, Gebara, OC, Aldrighi, JM, Vieira, N, Nussbacher, A, Pierri, H, Serro-Azul, J, Wajngarten, M, Rosano, G & Ramires, JA 2004, 'Acute effects of the use of estrogens in association with progestogens on postprandial triglyceridemia and vascular reactivity.', Arquivos Brasileiros de Cardiologia, vol. 83, no. 5.
Santos, S. C. ; Canashiro, Jaime Augusto ; Gebara, O. C. ; Aldrighi, José Mendes ; Vieira, Nubia ; Nussbacher, Amit ; Pierri, Humberto ; Serro-Azul, João ; Wajngarten, Maurício ; Rosano, Giuseppe ; Ramires, J. A. / Acute effects of the use of estrogens in association with progestogens on postprandial triglyceridemia and vascular reactivity. In: Arquivos Brasileiros de Cardiologia. 2004 ; Vol. 83, No. 5.
@article{3c4109ab75944adc834120491a07512e,
title = "Acute effects of the use of estrogens in association with progestogens on postprandial triglyceridemia and vascular reactivity.",
abstract = "OBJECTIVE: To assess whether hormone replacement therapy with estrogens in association with progestogens in postmenopausal hypertensive women alters postprandial triglyceridemia and vascular reactivity. METHODS: A double-blind, placebo-controlled, crossover study was carried out with 15 postmenopausal women (age range: 50 to 70 years, mean = 61.6 +/- 6 years) randomly assigned to 2 weeks of placebo or oral ingestion of 0.625 mg of equine conjugated estrogens and 2.5 mg of medroxyprogesterone, fed a high-fat diet (897 calories; 50.1{\%} fat). Vascular reactivity (VR - {\%} of vessel diameter variation in the fasting period and 2 hours after meals) was measured by using the automated ultrasound method. Lipid profile and glycemia during the fasting period and 2 hours after a high-fat meal were measured. RESULTS: With placebo, vascular reactivity (VR) decreased from 3.20 +/- 17{\%} during the fasting period to -2.1 +/- 30{\%} 2 hours after the meal (P = 0.041). With the hormone replacement therapy, vascular reactivity decreased from 6.14 +/- 27{\%} during the fasting period to - 0.05 +/- 18{\%} 2 hours after the meal (P = NS). Postprandial triglyceridemia increased as follows: 35 +/- 25{\%} with placebo; and 12 +/- 10{\%} with hormone replacement therapy (P <0.05). CONCLUSION: In postmenopausal hypertensive women, 2 weeks of hormone replacement with an association of estrogens and progestogens decreased hypertriglyceridemia after a high-fat meal, an effect that may reduce the endothelial dysfunction occurring in the postprandial period.",
author = "Santos, {S. C.} and Canashiro, {Jaime Augusto} and Gebara, {O. C.} and Aldrighi, {Jos{\'e} Mendes} and Nubia Vieira and Amit Nussbacher and Humberto Pierri and Jo{\~a}o Serro-Azul and Maur{\'i}cio Wajngarten and Giuseppe Rosano and Ramires, {J. A.}",
year = "2004",
month = "11",
language = "English",
volume = "83",
journal = "Arquivos Brasileiros de Cardiologia",
issn = "0066-782X",
publisher = "Arquivos Brasileiros de Cardiologia",
number = "5",

}

TY - JOUR

T1 - Acute effects of the use of estrogens in association with progestogens on postprandial triglyceridemia and vascular reactivity.

AU - Santos, S. C.

AU - Canashiro, Jaime Augusto

AU - Gebara, O. C.

AU - Aldrighi, José Mendes

AU - Vieira, Nubia

AU - Nussbacher, Amit

AU - Pierri, Humberto

AU - Serro-Azul, João

AU - Wajngarten, Maurício

AU - Rosano, Giuseppe

AU - Ramires, J. A.

PY - 2004/11

Y1 - 2004/11

N2 - OBJECTIVE: To assess whether hormone replacement therapy with estrogens in association with progestogens in postmenopausal hypertensive women alters postprandial triglyceridemia and vascular reactivity. METHODS: A double-blind, placebo-controlled, crossover study was carried out with 15 postmenopausal women (age range: 50 to 70 years, mean = 61.6 +/- 6 years) randomly assigned to 2 weeks of placebo or oral ingestion of 0.625 mg of equine conjugated estrogens and 2.5 mg of medroxyprogesterone, fed a high-fat diet (897 calories; 50.1% fat). Vascular reactivity (VR - % of vessel diameter variation in the fasting period and 2 hours after meals) was measured by using the automated ultrasound method. Lipid profile and glycemia during the fasting period and 2 hours after a high-fat meal were measured. RESULTS: With placebo, vascular reactivity (VR) decreased from 3.20 +/- 17% during the fasting period to -2.1 +/- 30% 2 hours after the meal (P = 0.041). With the hormone replacement therapy, vascular reactivity decreased from 6.14 +/- 27% during the fasting period to - 0.05 +/- 18% 2 hours after the meal (P = NS). Postprandial triglyceridemia increased as follows: 35 +/- 25% with placebo; and 12 +/- 10% with hormone replacement therapy (P <0.05). CONCLUSION: In postmenopausal hypertensive women, 2 weeks of hormone replacement with an association of estrogens and progestogens decreased hypertriglyceridemia after a high-fat meal, an effect that may reduce the endothelial dysfunction occurring in the postprandial period.

AB - OBJECTIVE: To assess whether hormone replacement therapy with estrogens in association with progestogens in postmenopausal hypertensive women alters postprandial triglyceridemia and vascular reactivity. METHODS: A double-blind, placebo-controlled, crossover study was carried out with 15 postmenopausal women (age range: 50 to 70 years, mean = 61.6 +/- 6 years) randomly assigned to 2 weeks of placebo or oral ingestion of 0.625 mg of equine conjugated estrogens and 2.5 mg of medroxyprogesterone, fed a high-fat diet (897 calories; 50.1% fat). Vascular reactivity (VR - % of vessel diameter variation in the fasting period and 2 hours after meals) was measured by using the automated ultrasound method. Lipid profile and glycemia during the fasting period and 2 hours after a high-fat meal were measured. RESULTS: With placebo, vascular reactivity (VR) decreased from 3.20 +/- 17% during the fasting period to -2.1 +/- 30% 2 hours after the meal (P = 0.041). With the hormone replacement therapy, vascular reactivity decreased from 6.14 +/- 27% during the fasting period to - 0.05 +/- 18% 2 hours after the meal (P = NS). Postprandial triglyceridemia increased as follows: 35 +/- 25% with placebo; and 12 +/- 10% with hormone replacement therapy (P <0.05). CONCLUSION: In postmenopausal hypertensive women, 2 weeks of hormone replacement with an association of estrogens and progestogens decreased hypertriglyceridemia after a high-fat meal, an effect that may reduce the endothelial dysfunction occurring in the postprandial period.

UR - http://www.scopus.com/inward/record.url?scp=28744451833&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=28744451833&partnerID=8YFLogxK

M3 - Article

C2 - 15543358

VL - 83

JO - Arquivos Brasileiros de Cardiologia

JF - Arquivos Brasileiros de Cardiologia

SN - 0066-782X

IS - 5

ER -