Efeitos agudos dos estrogênios associados a progestogênios sobre a trigliceridemia e reatividade vascular pós-prandial

Translated title of the contribution: Acute effects of the use of estrogens in association with progestogens on postprandial triglyceridemia and vascular reactivity

Silvio C M Santos, Jaime Augusto Canashiro, Otavio C E Gebara, José Mendes Aldrighi, Nubia Vieira, Amit Nussbacher, Humberto Pierri, Joâo Serro-Azul, Maurício Wajngarten, Giuseppe Rosano, Jose A F Ramires

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: To assess whether hormone replacement therapy with estrogens in association with progestogens in postmenopausal hypertensive women alters postprandial triglyceridemia and vascular reactivity. Methods: A double-blind, placebo-controlled, crossover study was carried out with 15 postmenopausal women (age range: 50 to 70 years, mean = 61.6 ± 6 years) randomly assigned to 2 weeks of placebo or oral ingestion of 0.625 mg of equine conjugated estrogens and 2.5 mg of medroxyprogesterone, fed a high-fat diet (897 calories; 50.1% fat). Vascular reactivity (VR - % of vessel diameter variation in the fasting period and 2 hours after meals) was measured by using the automated ultrasound method. Lipid profile and glycemia during the fasting period and 2 hours after a high-fat meal were measured. Results: With placebo, vascular reactivity (VR) decreased from 3.20 ± 17% during the fasting period to -2.1 ± 30% 2 hours after the meal (P=O.041). With the hormone replacement therapy, vascular reactivity decreased from 6.14 ± 27% during the fasting period to -0.05 ± 18% 2 hours after the meal (P=NS). Post-prandial triglyceridemia increased as follows: 35 ± 25% with placebo; and 12 ± 10% with hormone replacement therapy (P <0.05). Conclusion: In postmenopausal hypertensive women, 2 weeks of hormone replacement with an association of estrogens and progestogens decreased hypertriglyceridemia after a high-fat meal, an effect that may reduce the endothelial dysfunction occurring in the postprandial period.

Original languagePortuguese
Pages (from-to)385-395
Number of pages11
JournalArquivos Brasileiros de Cardiologia
Volume83
Issue number5
Publication statusPublished - Nov 2004

Fingerprint

Progestins
Blood Vessels
Meals
Estrogens
Fasting
Hormone Replacement Therapy
Placebos
Fats
Medroxyprogesterone
Postprandial Period
Conjugated (USP) Estrogens
Hypertriglyceridemia
High Fat Diet
Double-Blind Method
Cross-Over Studies
Eating
Hormones
Lipids

Keywords

  • Hormone replacement therapy
  • Triglyceridemia
  • Vascular endothelium

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Santos, S. C. M., Canashiro, J. A., Gebara, O. C. E., Aldrighi, J. M., Vieira, N., Nussbacher, A., ... Ramires, J. A. F. (2004). Efeitos agudos dos estrogênios associados a progestogênios sobre a trigliceridemia e reatividade vascular pós-prandial. Arquivos Brasileiros de Cardiologia, 83(5), 385-395.

Efeitos agudos dos estrogênios associados a progestogênios sobre a trigliceridemia e reatividade vascular pós-prandial. / Santos, Silvio C M; Canashiro, Jaime Augusto; Gebara, Otavio C E; Aldrighi, José Mendes; Vieira, Nubia; Nussbacher, Amit; Pierri, Humberto; Serro-Azul, Joâo; Wajngarten, Maurício; Rosano, Giuseppe; Ramires, Jose A F.

In: Arquivos Brasileiros de Cardiologia, Vol. 83, No. 5, 11.2004, p. 385-395.

Research output: Contribution to journalArticle

Santos, SCM, Canashiro, JA, Gebara, OCE, Aldrighi, JM, Vieira, N, Nussbacher, A, Pierri, H, Serro-Azul, J, Wajngarten, M, Rosano, G & Ramires, JAF 2004, 'Efeitos agudos dos estrogênios associados a progestogênios sobre a trigliceridemia e reatividade vascular pós-prandial', Arquivos Brasileiros de Cardiologia, vol. 83, no. 5, pp. 385-395.
Santos SCM, Canashiro JA, Gebara OCE, Aldrighi JM, Vieira N, Nussbacher A et al. Efeitos agudos dos estrogênios associados a progestogênios sobre a trigliceridemia e reatividade vascular pós-prandial. Arquivos Brasileiros de Cardiologia. 2004 Nov;83(5):385-395.
Santos, Silvio C M ; Canashiro, Jaime Augusto ; Gebara, Otavio C E ; Aldrighi, José Mendes ; Vieira, Nubia ; Nussbacher, Amit ; Pierri, Humberto ; Serro-Azul, Joâo ; Wajngarten, Maurício ; Rosano, Giuseppe ; Ramires, Jose A F. / Efeitos agudos dos estrogênios associados a progestogênios sobre a trigliceridemia e reatividade vascular pós-prandial. In: Arquivos Brasileiros de Cardiologia. 2004 ; Vol. 83, No. 5. pp. 385-395.
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AU - Aldrighi, José Mendes

AU - Vieira, Nubia

AU - Nussbacher, Amit

AU - Pierri, Humberto

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AU - Rosano, Giuseppe

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N2 - Objective: To assess whether hormone replacement therapy with estrogens in association with progestogens in postmenopausal hypertensive women alters postprandial triglyceridemia and vascular reactivity. Methods: A double-blind, placebo-controlled, crossover study was carried out with 15 postmenopausal women (age range: 50 to 70 years, mean = 61.6 ± 6 years) randomly assigned to 2 weeks of placebo or oral ingestion of 0.625 mg of equine conjugated estrogens and 2.5 mg of medroxyprogesterone, fed a high-fat diet (897 calories; 50.1% fat). Vascular reactivity (VR - % of vessel diameter variation in the fasting period and 2 hours after meals) was measured by using the automated ultrasound method. Lipid profile and glycemia during the fasting period and 2 hours after a high-fat meal were measured. Results: With placebo, vascular reactivity (VR) decreased from 3.20 ± 17% during the fasting period to -2.1 ± 30% 2 hours after the meal (P=O.041). With the hormone replacement therapy, vascular reactivity decreased from 6.14 ± 27% during the fasting period to -0.05 ± 18% 2 hours after the meal (P=NS). Post-prandial triglyceridemia increased as follows: 35 ± 25% with placebo; and 12 ± 10% with hormone replacement therapy (P <0.05). Conclusion: In postmenopausal hypertensive women, 2 weeks of hormone replacement with an association of estrogens and progestogens decreased hypertriglyceridemia after a high-fat meal, an effect that may reduce the endothelial dysfunction occurring in the postprandial period.

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