Abstract
Objective: To assess whether hormone replacement therapy with estrogens in association with progestogens in postmenopausal hypertensive women alters postprandial triglyceridemia and vascular reactivity. Methods: A double-blind, placebo-controlled, crossover study was carried out with 15 postmenopausal women (age range: 50 to 70 years, mean = 61.6 ± 6 years) randomly assigned to 2 weeks of placebo or oral ingestion of 0.625 mg of equine conjugated estrogens and 2.5 mg of medroxyprogesterone, fed a high-fat diet (897 calories; 50.1% fat). Vascular reactivity (VR - % of vessel diameter variation in the fasting period and 2 hours after meals) was measured by using the automated ultrasound method. Lipid profile and glycemia during the fasting period and 2 hours after a high-fat meal were measured. Results: With placebo, vascular reactivity (VR) decreased from 3.20 ± 17% during the fasting period to -2.1 ± 30% 2 hours after the meal (P=O.041). With the hormone replacement therapy, vascular reactivity decreased from 6.14 ± 27% during the fasting period to -0.05 ± 18% 2 hours after the meal (P=NS). Post-prandial triglyceridemia increased as follows: 35 ± 25% with placebo; and 12 ± 10% with hormone replacement therapy (P <0.05). Conclusion: In postmenopausal hypertensive women, 2 weeks of hormone replacement with an association of estrogens and progestogens decreased hypertriglyceridemia after a high-fat meal, an effect that may reduce the endothelial dysfunction occurring in the postprandial period.
| Original language | Portuguese |
|---|---|
| Pages (from-to) | 385-395 |
| Number of pages | 11 |
| Journal | Arquivos Brasileiros de Cardiologia |
| Volume | 83 |
| Issue number | 5 |
| Publication status | Published - Nov 2004 |
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Keywords
- Hormone replacement therapy
- Triglyceridemia
- Vascular endothelium
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Efeitos agudos dos estrogênios associados a progestogênios sobre a trigliceridemia e reatividade vascular pós-prandial. / Santos, Silvio C M; Canashiro, Jaime Augusto; Gebara, Otavio C E; Aldrighi, José Mendes; Vieira, Nubia; Nussbacher, Amit; Pierri, Humberto; Serro-Azul, Joâo; Wajngarten, Maurício; Rosano, Giuseppe; Ramires, Jose A F.
In: Arquivos Brasileiros de Cardiologia, Vol. 83, No. 5, 11.2004, p. 385-395.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Efeitos agudos dos estrogênios associados a progestogênios sobre a trigliceridemia e reatividade vascular pós-prandial
AU - Santos, Silvio C M
AU - Canashiro, Jaime Augusto
AU - Gebara, Otavio C E
AU - Aldrighi, José Mendes
AU - Vieira, Nubia
AU - Nussbacher, Amit
AU - Pierri, Humberto
AU - Serro-Azul, Joâo
AU - Wajngarten, Maurício
AU - Rosano, Giuseppe
AU - Ramires, Jose A F
PY - 2004/11
Y1 - 2004/11
N2 - Objective: To assess whether hormone replacement therapy with estrogens in association with progestogens in postmenopausal hypertensive women alters postprandial triglyceridemia and vascular reactivity. Methods: A double-blind, placebo-controlled, crossover study was carried out with 15 postmenopausal women (age range: 50 to 70 years, mean = 61.6 ± 6 years) randomly assigned to 2 weeks of placebo or oral ingestion of 0.625 mg of equine conjugated estrogens and 2.5 mg of medroxyprogesterone, fed a high-fat diet (897 calories; 50.1% fat). Vascular reactivity (VR - % of vessel diameter variation in the fasting period and 2 hours after meals) was measured by using the automated ultrasound method. Lipid profile and glycemia during the fasting period and 2 hours after a high-fat meal were measured. Results: With placebo, vascular reactivity (VR) decreased from 3.20 ± 17% during the fasting period to -2.1 ± 30% 2 hours after the meal (P=O.041). With the hormone replacement therapy, vascular reactivity decreased from 6.14 ± 27% during the fasting period to -0.05 ± 18% 2 hours after the meal (P=NS). Post-prandial triglyceridemia increased as follows: 35 ± 25% with placebo; and 12 ± 10% with hormone replacement therapy (P <0.05). Conclusion: In postmenopausal hypertensive women, 2 weeks of hormone replacement with an association of estrogens and progestogens decreased hypertriglyceridemia after a high-fat meal, an effect that may reduce the endothelial dysfunction occurring in the postprandial period.
AB - Objective: To assess whether hormone replacement therapy with estrogens in association with progestogens in postmenopausal hypertensive women alters postprandial triglyceridemia and vascular reactivity. Methods: A double-blind, placebo-controlled, crossover study was carried out with 15 postmenopausal women (age range: 50 to 70 years, mean = 61.6 ± 6 years) randomly assigned to 2 weeks of placebo or oral ingestion of 0.625 mg of equine conjugated estrogens and 2.5 mg of medroxyprogesterone, fed a high-fat diet (897 calories; 50.1% fat). Vascular reactivity (VR - % of vessel diameter variation in the fasting period and 2 hours after meals) was measured by using the automated ultrasound method. Lipid profile and glycemia during the fasting period and 2 hours after a high-fat meal were measured. Results: With placebo, vascular reactivity (VR) decreased from 3.20 ± 17% during the fasting period to -2.1 ± 30% 2 hours after the meal (P=O.041). With the hormone replacement therapy, vascular reactivity decreased from 6.14 ± 27% during the fasting period to -0.05 ± 18% 2 hours after the meal (P=NS). Post-prandial triglyceridemia increased as follows: 35 ± 25% with placebo; and 12 ± 10% with hormone replacement therapy (P <0.05). Conclusion: In postmenopausal hypertensive women, 2 weeks of hormone replacement with an association of estrogens and progestogens decreased hypertriglyceridemia after a high-fat meal, an effect that may reduce the endothelial dysfunction occurring in the postprandial period.
KW - Hormone replacement therapy
KW - Triglyceridemia
KW - Vascular endothelium
UR - http://www.scopus.com/inward/record.url?scp=9444236191&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=9444236191&partnerID=8YFLogxK
M3 - Articolo
AN - SCOPUS:9444236191
VL - 83
SP - 385
EP - 395
JO - Arquivos Brasileiros de Cardiologia
JF - Arquivos Brasileiros de Cardiologia
SN - 0066-782X
IS - 5
ER -