Acute ethanol administration increases biliary concentrations of total and unconjugated bilirubin in rabbits

Carlo di Padova, Raffaele Tritapepe, Franco di Padova, Paola Rovagnati, Nicola Dioguardi

Research output: Contribution to journalArticle

Abstract

Epidemiological investigations have revealed that alcoholic cirrhosis is associated with a high frequency of pigment gallstones, but only scantly information is available on the effects of ethanol on biliary secretion of bilirubin. We have injected intravenously 1.0 and 1.5 g/kg body wt of ethanol into six cholecystectomized rabbits with a common bile duct fistula. Experiments were performed ten days after surgery and a stream-splitting apparatus was interposed in the circuit in order to withdraw continuously biliary samples without interruption of enterohepatic bile circulation. Analysis of hourly data showed that both ethanol doses significantly increase the biliary concentration of total bilirubin, without affecting bile flow and lipid composition. Alcohol also promoted the efflux of unconjugated bilirubin into bile. The maximum effect occurred within the first 5 hr following alcohol administration. Thereafter the bile returned to normal. Since excessive concentrations of biliary unconjugated bilirubin favor pigment gallstone development, it can be speculated that alcohol acts as a risk factor for pigment lithiasis by enhancing the biliary levels of this form of pigment.

Original languageEnglish
Pages (from-to)1095-1099
Number of pages5
JournalDigestive Diseases and Sciences
Volume26
Issue number12
DOIs
Publication statusPublished - Dec 1981

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint Dive into the research topics of 'Acute ethanol administration increases biliary concentrations of total and unconjugated bilirubin in rabbits'. Together they form a unique fingerprint.

  • Cite this