Acute ethanol administration induces oxidative changes in rat pancreatic tissue

E. Altomare, I. Grattagliano, G. Vendemiale, V. Palmieri, G. Palasciano

Research output: Contribution to journalArticlepeer-review

Abstract

Background - There is mounting clinical evidence that ethanol toxicity to the pancreas is linked with glutathione depletion from oxidative stress but there is not experimental proof that this occurs. Aims and methods - The effect of acute ethanol ingestion (4 g/kg) on the pancreatic content of reduced (GSH) and oxidised (GSSG) glutathione, malondialdehyde (MDA), and carbonyl proteins were therefore studied in the rat. Results - Ethanol caused a significant reduction in GSH (p

Original languageEnglish
Pages (from-to)742-746
Number of pages5
JournalGut
Volume38
Issue number5
Publication statusPublished - 1996

Keywords

  • alcoholic pancreatic injury
  • glutathione
  • lipid peroxidation
  • protein oxidation

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint Dive into the research topics of 'Acute ethanol administration induces oxidative changes in rat pancreatic tissue'. Together they form a unique fingerprint.

Cite this