Acute ethanol administration induces oxidative changes in rat pancreatic tissue

E. Altomare; I. Grattagliano; G. Vendemiale; V. Palmieri; G. Palasciano

Acute ethanol administration induces oxidative changes in rat pancreatic tissue

E. Altomare, I. Grattagliano, G. Vendemiale, V. Palmieri, G. Palasciano

IRCCS Casa Sollievo della Sofferenza

Research output: Contribution to journal › Article › peer-review

Abstract

Background - There is mounting clinical evidence that ethanol toxicity to the pancreas is linked with glutathione depletion from oxidative stress but there is not experimental proof that this occurs. Aims and methods - The effect of acute ethanol ingestion (4 g/kg) on the pancreatic content of reduced (GSH) and oxidised (GSSG) glutathione, malondialdehyde (MDA), and carbonyl proteins were therefore studied in the rat. Results - Ethanol caused a significant reduction in GSH (p

Original language	English
Pages (from-to)	742-746
Number of pages	5
Journal	Gut
Volume	38
Issue number	5
Publication status	Published - 1996

Keywords

alcoholic pancreatic injury
glutathione
lipid peroxidation
protein oxidation

ASJC Scopus subject areas

Gastroenterology

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keywords = "alcoholic pancreatic injury, glutathione, lipid peroxidation, protein oxidation",

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T1 - Acute ethanol administration induces oxidative changes in rat pancreatic tissue

AU - Altomare, E.

AU - Grattagliano, I.

AU - Vendemiale, G.

AU - Palmieri, V.

AU - Palasciano, G.

PY - 1996

Y1 - 1996

N2 - Background - There is mounting clinical evidence that ethanol toxicity to the pancreas is linked with glutathione depletion from oxidative stress but there is not experimental proof that this occurs. Aims and methods - The effect of acute ethanol ingestion (4 g/kg) on the pancreatic content of reduced (GSH) and oxidised (GSSG) glutathione, malondialdehyde (MDA), and carbonyl proteins were therefore studied in the rat. Results - Ethanol caused a significant reduction in GSH (p

AB - Background - There is mounting clinical evidence that ethanol toxicity to the pancreas is linked with glutathione depletion from oxidative stress but there is not experimental proof that this occurs. Aims and methods - The effect of acute ethanol ingestion (4 g/kg) on the pancreatic content of reduced (GSH) and oxidised (GSSG) glutathione, malondialdehyde (MDA), and carbonyl proteins were therefore studied in the rat. Results - Ethanol caused a significant reduction in GSH (p

KW - alcoholic pancreatic injury

KW - glutathione

KW - lipid peroxidation

KW - protein oxidation

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