Abstract
Background - There is mounting clinical evidence that ethanol toxicity to the pancreas is linked with glutathione depletion from oxidative stress but there is not experimental proof that this occurs. Aims and methods - The effect of acute ethanol ingestion (4 g/kg) on the pancreatic content of reduced (GSH) and oxidised (GSSG) glutathione, malondialdehyde (MDA), and carbonyl proteins were therefore studied in the rat. Results - Ethanol caused a significant reduction in GSH (p
Original language | English |
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Pages (from-to) | 742-746 |
Number of pages | 5 |
Journal | Gut |
Volume | 38 |
Issue number | 5 |
Publication status | Published - 1996 |
Keywords
- alcoholic pancreatic injury
- glutathione
- lipid peroxidation
- protein oxidation
ASJC Scopus subject areas
- Gastroenterology