TY - JOUR
T1 - Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Oldest Adults
T2 - Predictors of In-Hospital Mortality and Need for Post-acute Care
AU - Spannella, Francesco
AU - Giulietti, Federico
AU - Cocci, Guido
AU - Landi, Laura
AU - Lombardi, Francesca Elena
AU - Borioni, Elisabetta
AU - Cenci, Alessandra
AU - Giordano, Piero
AU - Sarzani, Riccardo
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Objectives: Older age is associated with higher risk of death during acute exacerbations of chronic obstructive pulmonary disease (AE-COPD). Older patients hospitalized for AE-COPD often require post-acute care after acute phase. The aim of this study was to evaluate components of a comprehensive geriatric assessment and clinical/laboratory parameters, in order to find predictors of in-hospital mortality and need for post-acute care in patients aged 80 and older hospitalized for AE-COPD. Design: Prospective observational study. Setting: Hospital assessment. Participants: 121 patients consecutively admitted to an internal medicine and geriatrics department for AE-COPD. Measures: Activities of Daily Living (ADL) Hierarchy scale, Geriatric Index of Comorbidity, cognitive impairment, and clinical and laboratory parameters were collected. Results: Mean age: 87.0 ± 4.9 years; male: 54.5%. In-hospital mortality (18.2% of patients) was significantly associated with functional disability, high comorbidity, cognitive impairment, anemia, older age, lower albumin, higher N-terminal pro-B-type natriuretic peptide (NT-proBNP) and white blood cell levels, oral corticosteroids taken before admission, and no angiotensin-converting enzyme inhibitors or angiotensin receptor blockers taken before admission. In a stepwise logistic regression, functional dependence (P =.006), cognitive impairment (P =.038), and oral corticosteroids therapy before hospitalization (P =.035) were independently associated with a higher risk of in-hospital mortality. Among laboratory parameters, only NT-proBNP remained significantly associated with in-hospital mortality (P =.026). The need for post-acute care (18.2% of survivors) was associated with older age, higher admission PCO2, greater comorbidity, and cognitive impairment. In a stepwise logistic regression, only cognitive impairment (P =.016) and ln_PCO2 (P =.056) confirmed their association with the need for post-acute care. Conclusions/implications: Preadmission functional dependence, cognitive impairment, and corticosteroid use, plus elevated NT-proBNP at admission are risk factors for mortality during an AE-COPD in the oldest old. Therefore, medical providers should consider these, as well as the patient's advance directives, in planning hospital care. Furthermore, providers should arrange especially careful posthospitalization monitoring and frequent follow-up of individuals with cognitive impairment and baseline hypercapnia.
AB - Objectives: Older age is associated with higher risk of death during acute exacerbations of chronic obstructive pulmonary disease (AE-COPD). Older patients hospitalized for AE-COPD often require post-acute care after acute phase. The aim of this study was to evaluate components of a comprehensive geriatric assessment and clinical/laboratory parameters, in order to find predictors of in-hospital mortality and need for post-acute care in patients aged 80 and older hospitalized for AE-COPD. Design: Prospective observational study. Setting: Hospital assessment. Participants: 121 patients consecutively admitted to an internal medicine and geriatrics department for AE-COPD. Measures: Activities of Daily Living (ADL) Hierarchy scale, Geriatric Index of Comorbidity, cognitive impairment, and clinical and laboratory parameters were collected. Results: Mean age: 87.0 ± 4.9 years; male: 54.5%. In-hospital mortality (18.2% of patients) was significantly associated with functional disability, high comorbidity, cognitive impairment, anemia, older age, lower albumin, higher N-terminal pro-B-type natriuretic peptide (NT-proBNP) and white blood cell levels, oral corticosteroids taken before admission, and no angiotensin-converting enzyme inhibitors or angiotensin receptor blockers taken before admission. In a stepwise logistic regression, functional dependence (P =.006), cognitive impairment (P =.038), and oral corticosteroids therapy before hospitalization (P =.035) were independently associated with a higher risk of in-hospital mortality. Among laboratory parameters, only NT-proBNP remained significantly associated with in-hospital mortality (P =.026). The need for post-acute care (18.2% of survivors) was associated with older age, higher admission PCO2, greater comorbidity, and cognitive impairment. In a stepwise logistic regression, only cognitive impairment (P =.016) and ln_PCO2 (P =.056) confirmed their association with the need for post-acute care. Conclusions/implications: Preadmission functional dependence, cognitive impairment, and corticosteroid use, plus elevated NT-proBNP at admission are risk factors for mortality during an AE-COPD in the oldest old. Therefore, medical providers should consider these, as well as the patient's advance directives, in planning hospital care. Furthermore, providers should arrange especially careful posthospitalization monitoring and frequent follow-up of individuals with cognitive impairment and baseline hypercapnia.
KW - cognitive impairment
KW - COPD exacerbation
KW - disability
KW - in-hospital mortality
KW - NT-proBNP
KW - older adults
KW - post-acute care
UR - http://www.scopus.com/inward/record.url?scp=85062022827&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85062022827&partnerID=8YFLogxK
U2 - 10.1016/j.jamda.2019.01.125
DO - 10.1016/j.jamda.2019.01.125
M3 - Article
C2 - 30826270
AN - SCOPUS:85062022827
VL - 20
SP - 893
EP - 898
JO - Journal of the American Medical Directors Association
JF - Journal of the American Medical Directors Association
SN - 1525-8610
IS - 7
ER -