Acute exacerbations of COPD: Risk factors for failure and relapse

Marco Mantero, Paola Rogliani, Marta Di Pasquale, Eva Polverino, Ernesto Crisafulli, Monica Guerrero, Andrea Gramegna, Mario Cazzola, Francesco Blasi

Research output: Contribution to journalReview articlepeer-review


Acute exacerbations are a leading cause of worsening COPD in terms of lung function decline, quality of life, and survival. They also have a relevant economic burden on the health care system. Determining the risk factors for acute exacerbation and early relapse could be a crucial element for a better management of COPD patients. This review analyzes the current knowledge and underlines the main risk factors for recurrent acute exacerbations. Comprehensive evaluation of COPD patients during stable phase and exacerbation could contribute to prevent treatment failure and relapses.

Original languageEnglish
Pages (from-to)2687-2693
Number of pages7
JournalInternational Journal of COPD
Publication statusPublished - Sep 8 2017


  • COPD
  • Exacerbations
  • Infections
  • Prevention
  • Treatment

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Health Policy
  • Public Health, Environmental and Occupational Health


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