Acute flaccid paralysis due to Echovirus 30 in an immunosuppressed transplant recipient

Eleonora Mauri, Antonio Mastrangelo, Sara Testa, Laura Pellegrinelli, Elena Pariani, Sandro Binda, Fabio Triulzi, Sergio Barbieri, Cristina Bana, Giovanni Montini, Robertino Dilena

Research output: Contribution to journalArticle

Abstract

An Italian 13-year-old boy immunosuppressed due to kidney transplant presented in November 2018 with acute flaccid paralysis with anterior horn cell involvement resembling the clinical, radiological, and laboratory features of poliomyelitis. Enterovirus was molecularly identified in cerebral spinal fluid and stool samples and the sequence analysis of the VP1 gene of enterovirus genome revealed the presence of Echovirus 30 both in CSF and in stool samples. Echovirus 30 is an emerging neurotropic virus able to cause outbreaks of aseptic meningitis and meningoencephalitis all over the world, but acute flaccid paralysis is not a classical manifestation. A 6-month follow-up revealed a poor outcome with severe motor deficits and only slight improvement in disability. Clinicians must be aware of the possible role of Echovirus 30 in acute flaccid paralysis and active surveillance should consider the possible influence of immunosuppression on the symptoms caused by the widening spectrum of enterovirus infections.

Original languageEnglish
Pages (from-to)284-288
JournalJournal of NeuroVirology
Volume26
Issue number2
DOIs
Publication statusPublished - 2020

Keywords

  • Anterior horn cell disease
  • EMG
  • Epidemiology
  • MRI
  • Viral infections

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

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