TY - JOUR
T1 - Acute flaccid paralysis due to Echovirus 30 in an immunosuppressed transplant recipient
AU - Mauri, Eleonora
AU - Mastrangelo, Antonio
AU - Testa, Sara
AU - Pellegrinelli, Laura
AU - Pariani, Elena
AU - Binda, Sandro
AU - Triulzi, Fabio
AU - Barbieri, Sergio
AU - Bana, Cristina
AU - Montini, Giovanni
AU - Dilena, Robertino
PY - 2020
Y1 - 2020
N2 - An Italian 13-year-old boy immunosuppressed due to kidney transplant presented in November 2018 with acute flaccid paralysis with anterior horn cell involvement resembling the clinical, radiological, and laboratory features of poliomyelitis. Enterovirus was molecularly identified in cerebral spinal fluid and stool samples and the sequence analysis of the VP1 gene of enterovirus genome revealed the presence of Echovirus 30 both in CSF and in stool samples. Echovirus 30 is an emerging neurotropic virus able to cause outbreaks of aseptic meningitis and meningoencephalitis all over the world, but acute flaccid paralysis is not a classical manifestation. A 6-month follow-up revealed a poor outcome with severe motor deficits and only slight improvement in disability. Clinicians must be aware of the possible role of Echovirus 30 in acute flaccid paralysis and active surveillance should consider the possible influence of immunosuppression on the symptoms caused by the widening spectrum of enterovirus infections.
AB - An Italian 13-year-old boy immunosuppressed due to kidney transplant presented in November 2018 with acute flaccid paralysis with anterior horn cell involvement resembling the clinical, radiological, and laboratory features of poliomyelitis. Enterovirus was molecularly identified in cerebral spinal fluid and stool samples and the sequence analysis of the VP1 gene of enterovirus genome revealed the presence of Echovirus 30 both in CSF and in stool samples. Echovirus 30 is an emerging neurotropic virus able to cause outbreaks of aseptic meningitis and meningoencephalitis all over the world, but acute flaccid paralysis is not a classical manifestation. A 6-month follow-up revealed a poor outcome with severe motor deficits and only slight improvement in disability. Clinicians must be aware of the possible role of Echovirus 30 in acute flaccid paralysis and active surveillance should consider the possible influence of immunosuppression on the symptoms caused by the widening spectrum of enterovirus infections.
KW - Anterior horn cell disease
KW - EMG
KW - Epidemiology
KW - MRI
KW - Viral infections
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U2 - 10.1007/s13365-019-00812-4
DO - 10.1007/s13365-019-00812-4
M3 - Article
C2 - 31642013
AN - SCOPUS:85074467768
VL - 26
SP - 284
EP - 288
JO - Journal of NeuroVirology
JF - Journal of NeuroVirology
SN - 1355-0284
IS - 2
ER -