Acute fulminant hepatitis e virus genotype 3e infection: Description of the first case in Europe

Stefano Festa, Anna Rosa Garbuglia, Flavia Baccini, Francesco Panzuto, Maria Rosaria Capobianchi, Iolanda Santino, Flaminia Purchiaroni, Gianluigi Orgera, Gianfranco Delle Fave, Massimo Marignani

Research output: Contribution to journalArticlepeer-review


Hepatitis E virus (HEV) is the most important causative agent of acute hepatitis in developing countries. The disease is usually characterized by a self-limiting, benign course. However, when particular conditions coexist (pregnancy, old age, pre-existing liver disease) it may run an unfavourable course. To date, 4 HEV genotypes have been described. Historically, in the Western world, HEV infection was considered a travel-related disease, however in the last 2 decades a great number of non-travel-related autochthonous cases have been described, more often related to genotype 3 or 4 and in the context of zoonosis. We report the case of an elderly Italian man with an acute fulminant HEV infection genotype 3e that developed in the context of pre-existing liver disease; this is the first case of an unfavourable outcome associated with subgenotype 3e. The potential pathogenicity of this subgenotype together with the influence of host-related risk factors are discussed.

Original languageEnglish
Pages (from-to)727-731
Number of pages5
JournalScandinavian Journal of Infectious Diseases
Issue number10
Publication statusPublished - Oct 1 2014


  • Epidemiology
  • Fulminant
  • Genotype
  • Hepatitis E virus
  • Phylogenetic tree
  • Ribavirin

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Medicine(all)


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