Acute gastric dilatation after porcine islet transplantation in a cynomolgus monkey - Case history and review of the literature

Nathalie Campanile, Pleunie P P M Rood, Peter Yeh, Anna Casu, Rita Bottino, David K C Cooper

Research output: Contribution to journalArticlepeer-review

Abstract

We report a streptozotocin-induced diabetic cynomolgus monkey that developed acute gastric dilatation within the first week after intraportal porcine islet transplantation. The monkey presented with increasing anorexia and somnolence, associated with persistent metabolic acidosis. On physical examination, a diffuse mass was palpable in the abdomen. Because of its deteriorating clinical condition, the monkey was euthanized. Necropsy revealed acute gastric dilatation. Potential etiological factors, possible methods of prevention, and guidelines for management are reviewed, with special emphasis on the incidence and management of acute gastric dilatation in non-human primates.

Original languageEnglish
Pages (from-to)265-270
Number of pages6
JournalXenotransplantation
Volume14
Issue number3
DOIs
Publication statusPublished - May 2007

Keywords

  • Acute gastric dilatation
  • Cynomolgus monkey
  • Macaca fascicularis
  • Non-human primate
  • Xenotransplantation

ASJC Scopus subject areas

  • Immunology

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