Acute generalized exanthematous pustulosis in cystic echinococcosis: Immunological characterization

C. Cannistraci, I. L. La Parola, R. Riganò, F. Bassetti, E. Ortona, B. Santucci, Mauro Picardo, S. Siracusano

Research output: Contribution to journalArticle

Abstract

We report the first case, to the best of our knowledge, of a woman suffering from cystic echinococcosis of the liver, who consequently developed urticaria and acute generalized exanthematous pustolosis (AGEP). Serum immunoglobulin (Ig)E and IgG4 specific to Echinococcus granulosus antigens were detected by immunoblotting. Furthermore, the intracellular cytokine analysis revealed a prevalent T-helper 2 polarization. It can be reasoned that, while the presence of IgE specific to various E. granulosus allergens may be responsible for the chronic urticarial manifestations, the detection of IgG4 specific for E. granulosus antigens, forming immunocomplexes, may be related to the development of the AGEP.

Original languageEnglish
Pages (from-to)1245-1249
Number of pages5
JournalBritish Journal of Dermatology
Volume148
Issue number6
DOIs
Publication statusPublished - Jun 1 2003

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Keywords

  • Acute generalized exanthematous pustolosis
  • Echinococcosis
  • Immunoblotting
  • Intra-cellular cytokine detection

ASJC Scopus subject areas

  • Dermatology

Cite this

Cannistraci, C., La Parola, I. L., Riganò, R., Bassetti, F., Ortona, E., Santucci, B., Picardo, M., & Siracusano, S. (2003). Acute generalized exanthematous pustulosis in cystic echinococcosis: Immunological characterization. British Journal of Dermatology, 148(6), 1245-1249. https://doi.org/10.1046/j.1365-2133.2003.05346.x