Acute generalized exanthematous pustulosis induced by paroxetine in an adolescent girl

Chiara Mameli, Gianluca Tadini, Dario Cattaneo, Chiara Cerini, Gian Vincenzo Zuccotti

Research output: Contribution to journalArticlepeer-review


Acute generalized exanthematous pustulosis (AGEP) is a rare severe cutaneous reaction pattern, which, in the majority of cases, occurs in adults (males and females are equally affected). AGEP has rarely been described in the paediatric population (1, 2). Viral illnesses, vaccinations (e.g. anti-pneumococcal vaccine) and drugs (up to 90% of cases) have been implicated in the pathogenesis of AGEP (1, 2). Among drugs, the more commonly identified culprit agents are antibiotics (beta-lactams, macrolides, quinolones, pristinamycin, anti-infective sulphonamides), antimycotics (terbinafine, ketoconazole), calcium channel blockers (diltiazem), analgesics, antipyretics (paracetamol) and antimalarials (1). To date, however, the precise pathophysiological mechanism has not yet been identified and no report of AGEP caused by paroxetine, an antidepressant, has previously appeared in the English litterature.

Original languageEnglish
Pages (from-to)733-734
Number of pages2
JournalActa Dermato-Venereologica
Issue number6
Publication statusPublished - 2013

ASJC Scopus subject areas

  • Dermatology


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