Acute graft-versus-host disease in pediatric allogeneic hematopoietic stem cell transplantation. Single-center experience during 10 yr

Maura Faraci, Ilaria Caviglia, Erika Biral, Giuseppe Morreale, Stefano Giardino, Lucia Garbarino, Elio Castagnola, Giorgio Dini, Edoardo Lanino

Research output: Contribution to journalArticle

Abstract

a-GvHD may complicate allogeneic HSCT. In this retrospective single-center study, we evaluated incidence and risk factors of a-GvHD in 197 consecutive allogeneic pediatric HSCTs applying Glucksberg and NIH a-GvHD classifications. Among 179 eligible transplants, the cumulative incidence of grade 0-I a-GvHD was 48% and grade II-IV was 52%. None of the considered variables significantly influenced the incidence of grade II-IV a-GvHD. Malignancy and myeloablation were associated with an increased risk of classic a-GvHD (p <0.01). Seventy-two percentage of children are alive, with a significant difference in OS and TRM between grade 0 and I vs. grade II and IV a-GvHD; this observation was reproduced in the non-malignant setting, while only a disparity in TRM was evidenced in children with malignancy. In our experience, the incidence of a-GvHD was similar, regardless of donor type. Myeloablation and malignant disease represented the only risk factors for classic a-GvHD. Our results highlight the need for a better prevention of this complication in the non-malignant setting.

Original languageEnglish
Pages (from-to)887-893
Number of pages7
JournalPediatric Transplantation
Volume16
Issue number8
DOIs
Publication statusPublished - Dec 2012

Keywords

  • acute graft-versus-host disease
  • children
  • refractory acute graft-versus-host disease
  • unrelated and related donor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

Fingerprint Dive into the research topics of 'Acute graft-versus-host disease in pediatric allogeneic hematopoietic stem cell transplantation. Single-center experience during 10 yr'. Together they form a unique fingerprint.

  • Cite this