Acute haemodynamic effects of ibopamine and dopamine on isovolumic relaxation

Luciano Bernardi, Stefano Perlini, Francesco Soffiantino, Cosima Farilla, Alessandro Calciati, Pier Luigi Soldá, Maurizio Paro, Licia Merlo, Germano Marchetti, Giorgio Finardi

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Abstract

The effects of intraduodenal ibopamine (a new orally active inotropic agent claimed to have haemodynamic effects similar to dopamine) on isovolumic relaxation were monitored for 90 min in eight closed-chest anaesthetized dogs. Dopamine and epinine (ibopamine active metabolite) were also infused at graded doses. After 15 min, ibopamine (12 mg/kg) shortened the time constant of isovolumic relaxation, and increased stroke volume and mean aortic pressure. Peak positive dP/dt increased significantly only 10 min later. Heart rate did not change. Dopamine (10 μg/kg per min) similarly reduced the time constant, and increased stroke volume, mean aortic pressure, peak positive dP/dt and heart rate. Epinine (10 μg/kg per min) caused similar changes in peak positive dP/dt, stroke volume, mean aortic pressure, and accelerated time constant without raising the heart rate. Ibopamine and epinine therefore significantly improved the isovolumic relaxation phase, like dopamine, without however affecting the heart rate.

Original languageEnglish
Pages (from-to)415-424
Number of pages10
JournalEuropean Journal of Pharmacology
Volume164
Issue number3
DOIs
Publication statusPublished - May 30 1989

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Keywords

  • (Mathematical models)
  • Dopamine
  • Haemodynamics
  • Ibopamine
  • Isovolumic relaxation

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Bernardi, L., Perlini, S., Soffiantino, F., Farilla, C., Calciati, A., Luigi Soldá, P., Paro, M., Merlo, L., Marchetti, G., & Finardi, G. (1989). Acute haemodynamic effects of ibopamine and dopamine on isovolumic relaxation. European Journal of Pharmacology, 164(3), 415-424. https://doi.org/10.1016/0014-2999(89)90249-5