Acute hemorrhagic edema of young children: a prospective case series

Alessandra Ferrarini, Cecilia Benetti, Pietro Camozzi, Alessandro Ostini, Giacomo D. Simonetti, Gregorio P. Milani, Mario G. Bianchetti, Sebastiano A G Lava

Research output: Contribution to journalArticlepeer-review


Acute hemorrhagic edema of young children is a rare leukocytoclastic vasculitis that has been reported exclusively in small retrospective cases series, case reports, or quizzes. Considering that retrospective experience deserves confirmation in at least one observational prospective study, we present our experience with 16 children (12 boys and 4 girls, 5–28 months of age) affected by acute hemorrhagic edema. The patients were in good general conditions and with a low-grade or even absent fever. They presented with non-itching red to purpuric targetoid lesions not changing location within hours, with non-pitting and sometimes tender indurative swelling, and without mucous membrane involvement or scratch marks. Signs for articular, abdominal, or kidney involvement were absent. Antinuclear or antineutrophil cytoplasmic autoantibodies were never detected. The cases were managed symptomatically as outpatients and fully resolved within 4 weeks or less. No recurrence or familiarity was noted. Conclusion: This is the first prospective evaluation of hemorrhagic edema. Our findings emphasize its distinctive tetrad: a well-appearing child; targetoid lesions that do not change location within hours; non-pitting, sometimes tender edema; complete resolution without recurrence.(Table presented.)

Original languageEnglish
Pages (from-to)557-561
Number of pages5
JournalEuropean Journal of Pediatrics
Issue number4
Publication statusPublished - 2016


  • Acute hemorrhagic edema of young children
  • Antineutrophil cytoplasmic autoantibodies
  • Child
  • Finkelstein–Seidlmayer disease
  • Leukocytoclastic vasculitis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


Dive into the research topics of 'Acute hemorrhagic edema of young children: a prospective case series'. Together they form a unique fingerprint.

Cite this