Acute hemorrhagic leukoencephalitis in patients with acute myeloid leukemia in hematologic complete remission

Livio Pagano, Luigi Maria Larocca, Maria Luigia Vaccario, Carlo Masullo, Andrea Antinori, Francesco Pierconti, Tommaso Tartaglione, Paola Cattani, Luca Mele, Francesco Equitani, Giuseppe Leone

Research output: Contribution to journalArticle

Abstract

The authors describe the cases of three patients affected by acute myeloid leukemia, in complete remission, who rapidly developed neurologic symptoms leading to death. Neither clinical characteristics, nor radiological or microbiological procedures, allowed an etiological diagnosis of the neurologic syndrome. Post-mortem examination of the brain showed both macroscopic and microscopic findings compatible with acute hemorrhagic leukoencephalitis. The difficulty in distinguishing this entity from other CNS disease-related complications (e.g. leukemia infiltration, drug toxicity, hemorrhages) should not lead to an underestimation of the true incidence of this complication. We believe that with more attention to the possibility of this complication there would probably be both a greater possibility of collecting clinical informations about the real impact of this dramatic disease and a stronger hope of finding the right treatment for it.

Original languageEnglish
Pages (from-to)270-274
Number of pages5
JournalHaematologica
Volume84
Issue number3
Publication statusPublished - Mar 1999

Keywords

  • Acute hemorrhagic leukoencephalitis
  • Acute myeloid leukemia

ASJC Scopus subject areas

  • Hematology

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  • Cite this

    Pagano, L., Larocca, L. M., Vaccario, M. L., Masullo, C., Antinori, A., Pierconti, F., Tartaglione, T., Cattani, P., Mele, L., Equitani, F., & Leone, G. (1999). Acute hemorrhagic leukoencephalitis in patients with acute myeloid leukemia in hematologic complete remission. Haematologica, 84(3), 270-274.