Acute hypertension induces oxidative stress in brain tissues

Roberta Poulet, Maria T. Gentile, Carmine Vecchione, Maria Distaso, Alessandra Aretini, Luigi Fratta, Giovanni Russo, Cinara Echart, Angelo Maffei, Maria G. De Simoni, Giuseppe Lembo

Research output: Contribution to journalArticlepeer-review


Arterial hypertension is not only a major risk factor for cerebrovascular accidents, such as stroke and cerebral hemorrhage, but is also associated to milder forms of brain injury. One of the main causes of neurodegeneration is the increase in reactive oxygen species (ROS) that is also a common trait of hypertensive conditions, thus suggesting that such a mechanism could play a role even in the onset of hypertension-evoked brain injury. To investigate this issue, we have explored the effect of acute-induced hypertensive conditions on cerebral oxidative stress. To this aim, we have developed a mouse model of transverse aortic coarctation (TAC) between the two carotid arteries, which imposes acutely on the right brain hemisphere a dramatic increase in blood pressure. Our results show that hypertension acutely induced by aortic coarctation induces a breaking of the blood-brain barrier (BBB) and reactive astrocytosis through hyperperfusion, and evokes trigger factors of neurodegeneration such as oxidative stress and inflammation, similar to that observed in cerebral hypoperfusion. Moreover, the derived brain injury is mainly localized in selected brain areas controlling cognitive functions, such as the cortex and hippocampus, and could be a consequence of a defect in the BBB permeability. It is noteworthy to emphasize that, even if these latter events are not enough to produce ischemic/hemorrhagic injury, they are able to alter mechanisms fundamental for maintaining normal brain function, such as protein synthesis, which has a prominent role for memory formation and cortical plasticity.

Original languageEnglish
Pages (from-to)253-262
Number of pages10
JournalJournal of Cerebral Blood Flow and Metabolism
Issue number2
Publication statusPublished - Feb 2006


  • Blood-brain barrier
  • Free radicals
  • Hypertension

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)
  • Endocrinology, Diabetes and Metabolism


Dive into the research topics of 'Acute hypertension induces oxidative stress in brain tissues'. Together they form a unique fingerprint.

Cite this