Acute intradialytic well-being: Results of a clinical trial comparing polysulfone with cuprophan

Giulio Mingardi; Stefano Rota; Giancarlo Orlandini; Rocco Misiani; Stefania Bernareggi; Ornella Facci; Donatella Marchesi; Luca Bonetti; Arrigo Schieppati; Ariela Benigni; Antonella Piccinelli; Lucio Gualandris; Romana Licini; Aristide Mangili; Giuliano Mecca; Enza Poletti; Giacomo Tiraboschi; Claudio Grassi; Oscar Bracchi; Giovanni Pedroni; Agnese Meterangelis; Marco Lorenz; Patrizia Ondei; Luciano Pedrini; Giorgio Cozzi; Pietro Faranna; Marcello Borghi; Giovanni Vendramin; Margherita Massazza; Luciano Rusconi; Patrizia Giuliano

Acute intradialytic well-being: Results of a clinical trial comparing polysulfone with cuprophan

Giulio Mingardi, Stefano Rota, Giancarlo Orlandini, Rocco Misiani, Stefania Bernareggi, Ornella Facci, Donatella Marchesi, Luca Bonetti, Arrigo Schieppati, Ariela Benigni, Antonella Piccinelli, Lucio Gualandris, Romana Licini, Aristide Mangili, Giuliano Mecca, Enza Poletti, Giacomo Tiraboschi, Claudio Grassi, Oscar Bracchi, Giovanni PedroniAgnese Meterangelis, Marco Lorenz, Patrizia Ondei, Luciano Pedrini, Giorgio Cozzi, Pietro Faranna, Marcello Borghi, Giovanni Vendramin, Margherita Massazza, Luciano Rusconi, Patrizia Giuliano

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

We conducted a multicenter, randomized, double-blind, controlled clinical trial to compare the effects of a synthetic, high-flux polysulfone membrane with a standard cuprophan one on acute clinical complications during a diffusive dialysis procedure. The principal end-point, that is, the number of hypotensive episodes, was similar in polysulfone (39; 23.8%) and cuprophan (32; 19.5%). Likewise, no significant difference was found between the two membranes as far as the secondary end-point was concerned, that is, the effect on headache, nausea, pruritus and sense of well-being. We conclude that high-flux polysulfone, acutely used in standard diffusive dialysis, has no favorable influence on hypotensive episodes and does not affect some typical dialysis-related symptoms any differently from cuprophan membrane. The need is stressed for well-controlled studies specifically designed to assess the worth of new dialysis techniques and materials that may vastly raise the cost of dialysis treatment.

Original language	English
Pages (from-to)	714-719
Number of pages	6
Journal	Kidney International
Volume	40
Issue number	4
Publication status	Published - Oct 1991

ASJC Scopus subject areas

Nephrology

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Mingardi, G., Rota, S., Orlandini, G., Misiani, R., Bernareggi, S., Facci, O., Marchesi, D., Bonetti, L., Schieppati, A., Benigni, A., Piccinelli, A., Gualandris, L., Licini, R., Mangili, A., Mecca, G., Poletti, E., Tiraboschi, G., Grassi, C., Bracchi, O., ... Giuliano, P. (1991). Acute intradialytic well-being: Results of a clinical trial comparing polysulfone with cuprophan. Kidney International, 40(4), 714-719.

Mingardi, G, Rota, S, Orlandini, G, Misiani, R, Bernareggi, S, Facci, O, Marchesi, D, Bonetti, L, Schieppati, A, Benigni, A, Piccinelli, A, Gualandris, L, Licini, R, Mangili, A, Mecca, G, Poletti, E, Tiraboschi, G, Grassi, C, Bracchi, O, Pedroni, G, Meterangelis, A, Lorenz, M, Ondei, P, Pedrini, L, Cozzi, G, Faranna, P, Borghi, M, Vendramin, G, Massazza, M, Rusconi, L & Giuliano, P 1991, 'Acute intradialytic well-being: Results of a clinical trial comparing polysulfone with cuprophan', Kidney International, vol. 40, no. 4, pp. 714-719.

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abstract = "We conducted a multicenter, randomized, double-blind, controlled clinical trial to compare the effects of a synthetic, high-flux polysulfone membrane with a standard cuprophan one on acute clinical complications during a diffusive dialysis procedure. The principal end-point, that is, the number of hypotensive episodes, was similar in polysulfone (39; 23.8%) and cuprophan (32; 19.5%). Likewise, no significant difference was found between the two membranes as far as the secondary end-point was concerned, that is, the effect on headache, nausea, pruritus and sense of well-being. We conclude that high-flux polysulfone, acutely used in standard diffusive dialysis, has no favorable influence on hypotensive episodes and does not affect some typical dialysis-related symptoms any differently from cuprophan membrane. The need is stressed for well-controlled studies specifically designed to assess the worth of new dialysis techniques and materials that may vastly raise the cost of dialysis treatment.",

author = "Giulio Mingardi and Stefano Rota and Giancarlo Orlandini and Rocco Misiani and Stefania Bernareggi and Ornella Facci and Donatella Marchesi and Luca Bonetti and Arrigo Schieppati and Ariela Benigni and Antonella Piccinelli and Lucio Gualandris and Romana Licini and Aristide Mangili and Giuliano Mecca and Enza Poletti and Giacomo Tiraboschi and Claudio Grassi and Oscar Bracchi and Giovanni Pedroni and Agnese Meterangelis and Marco Lorenz and Patrizia Ondei and Luciano Pedrini and Giorgio Cozzi and Pietro Faranna and Marcello Borghi and Giovanni Vendramin and Margherita Massazza and Luciano Rusconi and Patrizia Giuliano",

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AU - Mingardi, Giulio

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AU - Orlandini, Giancarlo

AU - Misiani, Rocco

AU - Bernareggi, Stefania

AU - Facci, Ornella

AU - Marchesi, Donatella

AU - Bonetti, Luca

AU - Schieppati, Arrigo

AU - Benigni, Ariela

AU - Piccinelli, Antonella

AU - Gualandris, Lucio

AU - Licini, Romana

AU - Mangili, Aristide

AU - Mecca, Giuliano

AU - Poletti, Enza

AU - Tiraboschi, Giacomo

AU - Grassi, Claudio

AU - Bracchi, Oscar

AU - Pedroni, Giovanni

AU - Meterangelis, Agnese

AU - Lorenz, Marco

AU - Ondei, Patrizia

AU - Pedrini, Luciano

AU - Cozzi, Giorgio

AU - Faranna, Pietro

AU - Borghi, Marcello

AU - Vendramin, Giovanni

AU - Massazza, Margherita

AU - Rusconi, Luciano

AU - Giuliano, Patrizia

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N2 - We conducted a multicenter, randomized, double-blind, controlled clinical trial to compare the effects of a synthetic, high-flux polysulfone membrane with a standard cuprophan one on acute clinical complications during a diffusive dialysis procedure. The principal end-point, that is, the number of hypotensive episodes, was similar in polysulfone (39; 23.8%) and cuprophan (32; 19.5%). Likewise, no significant difference was found between the two membranes as far as the secondary end-point was concerned, that is, the effect on headache, nausea, pruritus and sense of well-being. We conclude that high-flux polysulfone, acutely used in standard diffusive dialysis, has no favorable influence on hypotensive episodes and does not affect some typical dialysis-related symptoms any differently from cuprophan membrane. The need is stressed for well-controlled studies specifically designed to assess the worth of new dialysis techniques and materials that may vastly raise the cost of dialysis treatment.

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Acute intradialytic well-being: Results of a clinical trial comparing polysulfone with cuprophan

Abstract

ASJC Scopus subject areas

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