Acute intradialytic well-being: Results of a clinical trial comparing polysulfone with cuprophan

Giulio Mingardi, Stefano Rota, Giancarlo Orlandini, Rocco Misiani, Stefania Bernareggi, Ornella Facci, Donatella Marchesi, Luca Bonetti, Arrigo Schieppati, Ariela Benigni, Antonella Piccinelli, Lucio Gualandris, Romana Licini, Aristide Mangili, Giuliano Mecca, Enza Poletti, Giacomo Tiraboschi, Claudio Grassi, Oscar Bracchi, Giovanni PedroniAgnese Meterangelis, Marco Lorenz, Patrizia Ondei, Luciano Pedrini, Giorgio Cozzi, Pietro Faranna, Marcello Borghi, Giovanni Vendramin, Margherita Massazza, Luciano Rusconi, Patrizia Giuliano

Research output: Contribution to journalArticlepeer-review

Abstract

We conducted a multicenter, randomized, double-blind, controlled clinical trial to compare the effects of a synthetic, high-flux polysulfone membrane with a standard cuprophan one on acute clinical complications during a diffusive dialysis procedure. The principal end-point, that is, the number of hypotensive episodes, was similar in polysulfone (39; 23.8%) and cuprophan (32; 19.5%). Likewise, no significant difference was found between the two membranes as far as the secondary end-point was concerned, that is, the effect on headache, nausea, pruritus and sense of well-being. We conclude that high-flux polysulfone, acutely used in standard diffusive dialysis, has no favorable influence on hypotensive episodes and does not affect some typical dialysis-related symptoms any differently from cuprophan membrane. The need is stressed for well-controlled studies specifically designed to assess the worth of new dialysis techniques and materials that may vastly raise the cost of dialysis treatment.

Original languageEnglish
Pages (from-to)714-719
Number of pages6
JournalKidney International
Volume40
Issue number4
Publication statusPublished - Oct 1991

ASJC Scopus subject areas

  • Nephrology

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