Acute kidney injury: Effect of hemodialysis membrane on Hgf and recovery of renal function

Carmelo Libetta, Pasquale Esposito, Vincenzo Sepe, Teresa Rampino, Manuela Zucchi, Michele Canevari, Antonio Dal Canton

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Acute kidney injury (AKI) is associated with a high mortality and morbidity rate. In this study we investigated whether dialysis membranes influence the recovery of renal function, through the regulation of hepatocyte growth factor (HGF). Design and methods: 21 patients were enrolled and assigned to hemodialysis (HD) with cellulose (CE, N=11) versus polymethylacrylate (PMMA, N=10) membranes in alternating order.HGF and IL-1 were measured in serum and in peripheral blood mononuclear cells (PBMC) supernatants collected immediately before the first HD session (T0), at 15. minutes (T15), at 240. minutes (T240) and after the last HD, when renal recovery occurred. Eight healthy volunteers were the controls (CON). Results: Time to renal function recovery was lower in CE than in PMMA patients. Serum HGF in HD patients was significantly higher than in CON. HGF levels were higher in CE than in PMMA patients at T15 (13.4. ±. 2.7 vs 8.9. ±. 3.0. ng/mL, P=0.004) and T240.At recovery, HGF levels decreased. IL-1 serum levels showed a similar trend (at T15 CE: 20.5. ±. 2.9 vs PMMA: 16.9. ±. 3.2. pg/mL, P=0.005). HGF release significantly increased in the course of HD, resulting in higher levels in CE than that in PMMA patients.Considering all the patients, basal HGF release negatively correlated with time to renal recovery (r2. =0.42, P

Original languageEnglish
Pages (from-to)103-108
Number of pages6
JournalClinical Biochemistry
Volume46
Issue number1-2
DOIs
Publication statusPublished - Jan 2013

Keywords

  • Acute kidney injury
  • Biocompatibility
  • Dialytic membranes
  • Hepatocyte growth factor
  • IL-1
  • Renal recovery

ASJC Scopus subject areas

  • Clinical Biochemistry

Fingerprint

Dive into the research topics of 'Acute kidney injury: Effect of hemodialysis membrane on Hgf and recovery of renal function'. Together they form a unique fingerprint.

Cite this