Acute kidney injury in a preterm infant homozygous for the C3435T polymorphism in the ABCB1 gene given oral morphine

Laura Pogliani, Chiara Mameli, Dario Cattaneo, Emilio Clementi, Fabio Meneghin, Sonia Radice, Simona Bruno, Gian Vincenzo Zuccotti

Research output: Contribution to journalArticle

Abstract

A 34-week infant born from a mother with a history of drug abuse developed neonatal abstinence syndrome (NAS) in the first hours of life. Urine drug screening was positive for cocaine and heroin. The infant developed acute kidney injury and bilateral hydronephrosis while receiving oral morphine for control of NAS. Cessation of morphine therapy and urinary catheterization resulted in a rapid and complete resolution of the symptoms. Our patient was homozygous for the C3435T polymorphism in the ABCB1 gene, a polymorphism previously associated with impaired P-glycoprotein activity. We hypothesize that acute renal toxicity was related to accumulation of morphine within urothelial cells due to genetically determined impaired P-glycoprotein activity.

Original languageEnglish
Pages (from-to)431-433
Number of pages3
JournalClinical Kidney Journal
Volume5
Issue number5
DOIs
Publication statusPublished - Oct 2012

Keywords

  • acute kidney injury
  • morphine
  • pharmacogenetics
  • preterm infant

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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    Pogliani, L., Mameli, C., Cattaneo, D., Clementi, E., Meneghin, F., Radice, S., Bruno, S., & Zuccotti, G. V. (2012). Acute kidney injury in a preterm infant homozygous for the C3435T polymorphism in the ABCB1 gene given oral morphine. Clinical Kidney Journal, 5(5), 431-433. https://doi.org/10.1093/ckj/sfs099