Acute Kidney Injury in Elderly Patients with Non-ST Elevation Acute Coronary Syndrome: Insights from the Italian Elderly: ACS Study

Anna Toso, Stefano De Servi, Mario Leoncini, Nuccia Morici, Ernesto Murena, Roberto Antonicelli, Claudio Cavallini, Anna Sonia Petronio, Giuseppe Steffenino, Federico Piscione, Francesco Bellandi, Stefano Savonitto

Research output: Contribution to journalArticle

Abstract

We examined the incidence and predictors of acute kidney injury (AKI) in elderly patients (≥75 years) enrolled in the prospective Italian Elderly acute coronary syndrome (ACS) study and explored the impact of AKI on clinical outcome. Acute kidney injury, defined according to the Acute Kidney Injury Network criteria, occurred in 128 (21%) of 615 patients. Patients submitted to coronary angiographic procedures did not present higher rate of AKI. The only baseline variables independently associated with AKI development were creatinine clearance (odds ratio [OR]: 0.98; 95% confidence interval [CI]: 0.97-0.99) and left ventricular ejection fraction (OR: 0.98; 95% CI: 0.96-0.99). Adverse clinical events were significantly higher in patients who developed AKI. After multivariable adjustment, AKI (hazard ratio: 2.73; 95% CI: 1.87-4.0) was an independent predictor of all-cause mortality within 1 year.

Original languageEnglish
Pages (from-to)826-830
Number of pages5
JournalAngiology
Volume66
Issue number9
DOIs
Publication statusPublished - Oct 9 2015

Keywords

  • acute coronary syndrome
  • acute kidney injury
  • elderly

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

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    Toso, A., Servi, S. D., Leoncini, M., Morici, N., Murena, E., Antonicelli, R., Cavallini, C., Petronio, A. S., Steffenino, G., Piscione, F., Bellandi, F., & Savonitto, S. (2015). Acute Kidney Injury in Elderly Patients with Non-ST Elevation Acute Coronary Syndrome: Insights from the Italian Elderly: ACS Study. Angiology, 66(9), 826-830. https://doi.org/10.1177/0003319714567738