Acute leukemia presenting a variant Ph chromosome with p190 expression, dup 3q and -7, developed after malignant lymphoma treated with alkylating agents and topoisomerase II inhibitors

G. Alimena, M. Cedrone, M. Nanni, M. R. De Cuia, F. Lo Coco, V. De Sanctis, G. Cimino, M. Mancini

Research output: Contribution to journalArticle

Abstract

We describe the occurrence of a variant Ph chromosome (v-Ph) in a therapy-related acute leukemia (s-AL), developed after 8-year treatment for a NHL with alkylating agents, anthracyclines and topoisomerase II inhibitors. The v-Ph originated from a complex t(2;9;22) translocation, expressed a p190(bcr-abl) fusion protein, and was associated to other specific changes, such as dup(3) (q21q26) and -7. The s-AL, apparently not preceded by a dysplastic phase, presented with signs of trilineage dysplasia with 10% micromegakaryocytes; it was classified as M5 according to FAB. The complex genetic changes observed in the present case may reflect distinct leukemogenic effects by different chemotherapeutic agents.

Original languageEnglish
Pages (from-to)1483-1486
Number of pages4
JournalLeukemia
Volume9
Issue number9
Publication statusPublished - 1995

Keywords

  • p190(bcr-abl)
  • Therapy-related leukemia
  • Variant Ph chromosome

ASJC Scopus subject areas

  • Cancer Research
  • Hematology

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