TY - JOUR
T1 - Acute liver injury following Garcinia cambogia weight-loss supplementation
T2 - case series and literature review
AU - Crescioli, Giada
AU - Lombardi, Niccolò
AU - Bettiol, Alessandra
AU - Marconi, Ettore
AU - Risaliti, Filippo
AU - Bertoni, Michele
AU - Menniti Ippolito, Francesca
AU - Maggini, Valentina
AU - Gallo, Eugenia
AU - Firenzuoli, Fabio
AU - Vannacci, Alfredo
PY - 2018/9
Y1 - 2018/9
N2 - Herbal weight-loss supplements are sold as self-medication products, and are often used under the misconception that their natural origin guarantees their safety. Food supplements are not required to provide any benefit/risk profile evaluation before marketing; however, possible risks associated with use of herbal extracts in food supplements are becoming more and more documented in the literature. Some herbs are listed as the leading cause of herb-induced liver injury, with a severe or potentially lethal clinical course, and unpredictable herb-drug interactions. Garcinia cambogia (GC) extract and GC-containing products are some of the most popular dietary supplements currently marketed for weight loss. Here, we present four cases of acute liver failure in women taking GC extract for weight loss, and a literature review of clinical evidences about hepatic toxicity in patients taking dietary supplements containing GC extract.
AB - Herbal weight-loss supplements are sold as self-medication products, and are often used under the misconception that their natural origin guarantees their safety. Food supplements are not required to provide any benefit/risk profile evaluation before marketing; however, possible risks associated with use of herbal extracts in food supplements are becoming more and more documented in the literature. Some herbs are listed as the leading cause of herb-induced liver injury, with a severe or potentially lethal clinical course, and unpredictable herb-drug interactions. Garcinia cambogia (GC) extract and GC-containing products are some of the most popular dietary supplements currently marketed for weight loss. Here, we present four cases of acute liver failure in women taking GC extract for weight loss, and a literature review of clinical evidences about hepatic toxicity in patients taking dietary supplements containing GC extract.
U2 - 10.1007/s11739-018-1880-4
DO - 10.1007/s11739-018-1880-4
M3 - Article
C2 - 29802521
VL - 13
SP - 857
EP - 872
JO - Internal and Emergency Medicine
JF - Internal and Emergency Medicine
SN - 1828-0447
IS - 6
ER -