Acute liver injury following Garcinia cambogia weight-loss supplementation: case series and literature review

Giada Crescioli, Niccolò Lombardi, Alessandra Bettiol, Ettore Marconi, Filippo Risaliti, Michele Bertoni, Francesca Menniti Ippolito, Valentina Maggini, Eugenia Gallo, Fabio Firenzuoli, Alfredo Vannacci

Research output: Contribution to journalArticlepeer-review

Abstract

Herbal weight-loss supplements are sold as self-medication products, and are often used under the misconception that their natural origin guarantees their safety. Food supplements are not required to provide any benefit/risk profile evaluation before marketing; however, possible risks associated with use of herbal extracts in food supplements are becoming more and more documented in the literature. Some herbs are listed as the leading cause of herb-induced liver injury, with a severe or potentially lethal clinical course, and unpredictable herb-drug interactions. Garcinia cambogia (GC) extract and GC-containing products are some of the most popular dietary supplements currently marketed for weight loss. Here, we present four cases of acute liver failure in women taking GC extract for weight loss, and a literature review of clinical evidences about hepatic toxicity in patients taking dietary supplements containing GC extract.

Original languageEnglish
Pages (from-to)857-872
Number of pages16
JournalInternal and Emergency Medicine
Volume13
Issue number6
DOIs
Publication statusPublished - Sep 2018

Fingerprint Dive into the research topics of 'Acute liver injury following Garcinia cambogia weight-loss supplementation: case series and literature review'. Together they form a unique fingerprint.

Cite this