Abstract
The aim of this work was to evaluate in a double-blind controlled study the effect of a pure muscle relaxant drug (dantrolene sodium) in the symptomatic treatment of uncomplicated low back pain in 20 patients. The one capsule daily dosage (25 mg) was given for 4 days. Patients treated with dantrolene sodium obtained an improvement of muscle contracture (p <0.001 versus placebo), VAS pain measurement, and pain behavior (both p <0.001 versus placebo). The electromyogram (EMG) parameters (i.e., the antalgic reflex motor unit firing) improved in the treated group (p <0.01 versus placebo). Data show the possibility of treating uncomplicated acute low back pain with a pure muscle relaxant. Some basic physiopathological aspects of low back pain are also discussed.
Original language | English |
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Pages (from-to) | 81-88 |
Number of pages | 8 |
Journal | Clinical Journal of Pain |
Volume | 4 |
Issue number | 2 |
Publication status | Published - 1988 |
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine