Acute low back pain. Symptomatic treatment with a muscle relaxant drug

R. Casale

Research output: Contribution to journalArticlepeer-review


The aim of this work was to evaluate in a double-blind controlled study the effect of a pure muscle relaxant drug (dantrolene sodium) in the symptomatic treatment of uncomplicated low back pain in 20 patients. The one capsule daily dosage (25 mg) was given for 4 days. Patients treated with dantrolene sodium obtained an improvement of muscle contracture (p <0.001 versus placebo), VAS pain measurement, and pain behavior (both p <0.001 versus placebo). The electromyogram (EMG) parameters (i.e., the antalgic reflex motor unit firing) improved in the treated group (p <0.01 versus placebo). Data show the possibility of treating uncomplicated acute low back pain with a pure muscle relaxant. Some basic physiopathological aspects of low back pain are also discussed.

Original languageEnglish
Pages (from-to)81-88
Number of pages8
JournalClinical Journal of Pain
Issue number2
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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