Acute lymphoblastic leukemia in children with associated genetic conditions other than Down's syndrome. The AIEOP experience

Ottavio Ziino, Roberta Rondelli, Concetta Micalizzi, Matteo Luciani, Valentino Conter, Maurizio Aricò

Research output: Contribution to journalArticle

Abstract

We retrospectively reviewed the databases of seven studies on acute lymphoblastic leukemia (ALL) by the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) to identify patients with associated genetic disease, other than Down's syndrome. Forty-two patients were reported to have associated genetic conditions that included β-thalassemia (n=10), ataxia- telangiectasia (n=5), neurofibromatosis (n=3), Sotos syndrome (n=2) and other individual conditions. Patients with ataxia-telangiectasia, all with T-cell ALL, had a higher frequency of adverse events.

Original languageEnglish
Pages (from-to)139-140
Number of pages2
JournalHaematologica
Volume91
Issue number1
Publication statusPublished - Jan 2006

Keywords

  • Acute lymphoblastic leukemia
  • Genetic diseases
  • Malformation

ASJC Scopus subject areas

  • Hematology

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