Abstract
We describe a case of ALL with the t(4;11) (q21;q23) translocation in which both surface markers and molecular analyses suggest an unusual early T cell involvement. While the morphologic and cytochemical studies showed an undifferentiated pattern, immunophenotypic data were suggestive of a very immature cell population which stained only for TdT and CD7. Moreover, in contrast to previous reports but in agreement with the immunologic findings, the IgH gene region retained a germ-line configuration. T cell receptor β and γ chain gene loci also showed a germline pattern, in accordance with the expansion of immature CD7+, TdT+ T cells.
Original language | English |
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Pages (from-to) | 79-82 |
Number of pages | 4 |
Journal | Leukemia |
Volume | 3 |
Issue number | 1 |
Publication status | Published - 1989 |
ASJC Scopus subject areas
- Cancer Research
- Hematology