Acute lymphoblastic leukemia with the 4;11 translocation exhibiting early T cell features

F. Lo Coco, P. F. Di Celle, G. Alimena, G. De Rossi, R. Gastaldi, G. Casorati, G. Saglio, R. Foa

Research output: Contribution to journalArticlepeer-review

Abstract

We describe a case of ALL with the t(4;11) (q21;q23) translocation in which both surface markers and molecular analyses suggest an unusual early T cell involvement. While the morphologic and cytochemical studies showed an undifferentiated pattern, immunophenotypic data were suggestive of a very immature cell population which stained only for TdT and CD7. Moreover, in contrast to previous reports but in agreement with the immunologic findings, the IgH gene region retained a germ-line configuration. T cell receptor β and γ chain gene loci also showed a germline pattern, in accordance with the expansion of immature CD7+, TdT+ T cells.

Original languageEnglish
Pages (from-to)79-82
Number of pages4
JournalLeukemia
Volume3
Issue number1
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Cancer Research
  • Hematology

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