Acute lymphocytic and myelomonocytic leukemia associated with low platelet counts and a 21q- marker chromosome

Giuliana Alimena, Bruno Dallapiccola, Maria Rosaria De Cuia, Franco Mandelli, Felix Mitelman

Research output: Contribution to journalArticle

Abstract

A terminal deletion of the long arm of one chromosome 21 at band q21 was found in two patients with acute leukemia and a low platelet count: one case of acute myelomonocytic leukemia and one case of acute lymphocytic leukemia. The segment deleted from chromosome 21 could not be found translocated to any other chromosome of the complement. The results indicate that the 21q- marker chromosome may be due to a true deletion and that the marker is not specific for primary thrombocythemia or other myeloproliferative disorders associated with thrombocytosis.

Original languageEnglish
Pages (from-to)329-331
Number of pages3
JournalHuman Genetics
Volume57
Issue number3
DOIs
Publication statusPublished - May 1981

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Leukemia, Myelomonocytic, Acute
Chromosomes, Human, Pair 21
Platelet Count
Genetic Markers
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Essential Thrombocythemia
Thrombocytosis
Myeloproliferative Disorders
Leukemia
Chromosomes

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Acute lymphocytic and myelomonocytic leukemia associated with low platelet counts and a 21q- marker chromosome. / Alimena, Giuliana; Dallapiccola, Bruno; De Cuia, Maria Rosaria; Mandelli, Franco; Mitelman, Felix.

In: Human Genetics, Vol. 57, No. 3, 05.1981, p. 329-331.

Research output: Contribution to journalArticle

Alimena, Giuliana ; Dallapiccola, Bruno ; De Cuia, Maria Rosaria ; Mandelli, Franco ; Mitelman, Felix. / Acute lymphocytic and myelomonocytic leukemia associated with low platelet counts and a 21q- marker chromosome. In: Human Genetics. 1981 ; Vol. 57, No. 3. pp. 329-331.
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