Acute lymphocytic and myelomonocytic leukemia associated with low platelet counts and a 21q- marker chromosome

Giuliana Alimena; Bruno Dallapiccola; Maria Rosaria De Cuia; Franco Mandelli; Felix Mitelman

doi:10.1007/BF00278957

Acute lymphocytic and myelomonocytic leukemia associated with low platelet counts and a 21q- marker chromosome

Giuliana Alimena, Bruno Dallapiccola, Maria Rosaria De Cuia, Franco Mandelli, Felix Mitelman

Ospedale Pediatrico Bambino Gesu

Research output: Contribution to journal › Article › peer-review

Abstract

A terminal deletion of the long arm of one chromosome 21 at band q21 was found in two patients with acute leukemia and a low platelet count: one case of acute myelomonocytic leukemia and one case of acute lymphocytic leukemia. The segment deleted from chromosome 21 could not be found translocated to any other chromosome of the complement. The results indicate that the 21q- marker chromosome may be due to a true deletion and that the marker is not specific for primary thrombocythemia or other myeloproliferative disorders associated with thrombocytosis.

Original language	English
Pages (from-to)	329-331
Number of pages	3
Journal	Human Genetics
Volume	57
Issue number	3
DOIs	https://doi.org/10.1007/BF00278957
Publication status	Published - May 1981

ASJC Scopus subject areas

Genetics(clinical)
Genetics

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title = "Acute lymphocytic and myelomonocytic leukemia associated with low platelet counts and a 21q- marker chromosome",

abstract = "A terminal deletion of the long arm of one chromosome 21 at band q21 was found in two patients with acute leukemia and a low platelet count: one case of acute myelomonocytic leukemia and one case of acute lymphocytic leukemia. The segment deleted from chromosome 21 could not be found translocated to any other chromosome of the complement. The results indicate that the 21q- marker chromosome may be due to a true deletion and that the marker is not specific for primary thrombocythemia or other myeloproliferative disorders associated with thrombocytosis.",

author = "Giuliana Alimena and Bruno Dallapiccola and {De Cuia}, {Maria Rosaria} and Franco Mandelli and Felix Mitelman",

year = "1981",

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AU - De Cuia, Maria Rosaria

AU - Mandelli, Franco

AU - Mitelman, Felix

PY - 1981/5

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AB - A terminal deletion of the long arm of one chromosome 21 at band q21 was found in two patients with acute leukemia and a low platelet count: one case of acute myelomonocytic leukemia and one case of acute lymphocytic leukemia. The segment deleted from chromosome 21 could not be found translocated to any other chromosome of the complement. The results indicate that the 21q- marker chromosome may be due to a true deletion and that the marker is not specific for primary thrombocythemia or other myeloproliferative disorders associated with thrombocytosis.

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