Abstract
A terminal deletion of the long arm of one chromosome 21 at band q21 was found in two patients with acute leukemia and a low platelet count: one case of acute myelomonocytic leukemia and one case of acute lymphocytic leukemia. The segment deleted from chromosome 21 could not be found translocated to any other chromosome of the complement. The results indicate that the 21q- marker chromosome may be due to a true deletion and that the marker is not specific for primary thrombocythemia or other myeloproliferative disorders associated with thrombocytosis.
| Original language | English |
|---|---|
| Pages (from-to) | 329-331 |
| Number of pages | 3 |
| Journal | Human Genetics |
| Volume | 57 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - May 1981 |
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ASJC Scopus subject areas
- Genetics(clinical)
- Genetics
Cite this
Acute lymphocytic and myelomonocytic leukemia associated with low platelet counts and a 21q- marker chromosome. / Alimena, Giuliana; Dallapiccola, Bruno; De Cuia, Maria Rosaria; Mandelli, Franco; Mitelman, Felix.
In: Human Genetics, Vol. 57, No. 3, 05.1981, p. 329-331.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Acute lymphocytic and myelomonocytic leukemia associated with low platelet counts and a 21q- marker chromosome
AU - Alimena, Giuliana
AU - Dallapiccola, Bruno
AU - De Cuia, Maria Rosaria
AU - Mandelli, Franco
AU - Mitelman, Felix
PY - 1981/5
Y1 - 1981/5
N2 - A terminal deletion of the long arm of one chromosome 21 at band q21 was found in two patients with acute leukemia and a low platelet count: one case of acute myelomonocytic leukemia and one case of acute lymphocytic leukemia. The segment deleted from chromosome 21 could not be found translocated to any other chromosome of the complement. The results indicate that the 21q- marker chromosome may be due to a true deletion and that the marker is not specific for primary thrombocythemia or other myeloproliferative disorders associated with thrombocytosis.
AB - A terminal deletion of the long arm of one chromosome 21 at band q21 was found in two patients with acute leukemia and a low platelet count: one case of acute myelomonocytic leukemia and one case of acute lymphocytic leukemia. The segment deleted from chromosome 21 could not be found translocated to any other chromosome of the complement. The results indicate that the 21q- marker chromosome may be due to a true deletion and that the marker is not specific for primary thrombocythemia or other myeloproliferative disorders associated with thrombocytosis.
UR - http://www.scopus.com/inward/record.url?scp=0019462906&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019462906&partnerID=8YFLogxK
U2 - 10.1007/BF00278957
DO - 10.1007/BF00278957
M3 - Article
C2 - 6941924
AN - SCOPUS:0019462906
VL - 57
SP - 329
EP - 331
JO - Human Genetics
JF - Human Genetics
SN - 0340-6717
IS - 3
ER -