Acute megakaryocytic leukemia in essential thrombocythemia: An unusual evolution?

Franca Radaelli, Rita Mazza, Elisabetta Curioni, Alberto Ciani, Mauro Pomati, Anna Teresa Maiolo

Research output: Contribution to journalArticle


Essential thrombocythemia (ET) is a chronic myeloproliferative disorder that can rarely undergo leukemic transformation either in treated (3-7%) or untreated patients (1%). Evolution to myeloblastic or myelomonoblastic acute leukemia is commonly described in the literature, whereas lymphatic and megakaryocytic forms are considered unusual. Here, we report three cases of acute megakaryocytic leukemia (LMA-M7) among 11 acute leukemic transformations observed in our series of 321 ET patients. LMA-M7 was diagnosed employing immunophenotyping according to FAB criteria. These recurrences of LMA M7 suggest that this kind of evolution cannot be considered rare or casual in ET.

Original languageEnglish
Pages (from-to)108-111
Number of pages4
JournalEuropean Journal of Haematology
Issue number2
Publication statusPublished - Aug 1 2002


  • Essential thrombocythemia
  • Evolution
  • Megakaryocytic leukemia

ASJC Scopus subject areas

  • Hematology

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