Acute megakaryocytic leukemia in essential thrombocythemia: An unusual evolution?

Franca Radaelli, Rita Mazza, Elisabetta Curioni, Alberto Ciani, Mauro Pomati, Anna Teresa Maiolo

Research output: Contribution to journalArticle

Abstract

Essential thrombocythemia (ET) is a chronic myeloproliferative disorder that can rarely undergo leukemic transformation either in treated (3-7%) or untreated patients (1%). Evolution to myeloblastic or myelomonoblastic acute leukemia is commonly described in the literature, whereas lymphatic and megakaryocytic forms are considered unusual. Here, we report three cases of acute megakaryocytic leukemia (LMA-M7) among 11 acute leukemic transformations observed in our series of 321 ET patients. LMA-M7 was diagnosed employing immunophenotyping according to FAB criteria. These recurrences of LMA M7 suggest that this kind of evolution cannot be considered rare or casual in ET.

Original languageEnglish
Pages (from-to)108-111
Number of pages4
JournalEuropean Journal of Haematology
Volume69
Issue number2
DOIs
Publication statusPublished - Aug 1 2002

Fingerprint

Leukemia, Megakaryoblastic, Acute
Essential Thrombocythemia
Myeloproliferative Disorders
Immunophenotyping
Leukemia
Recurrence

Keywords

  • Essential thrombocythemia
  • Evolution
  • Megakaryocytic leukemia

ASJC Scopus subject areas

  • Hematology

Cite this

Acute megakaryocytic leukemia in essential thrombocythemia : An unusual evolution? / Radaelli, Franca; Mazza, Rita; Curioni, Elisabetta; Ciani, Alberto; Pomati, Mauro; Maiolo, Anna Teresa.

In: European Journal of Haematology, Vol. 69, No. 2, 01.08.2002, p. 108-111.

Research output: Contribution to journalArticle

Radaelli, Franca ; Mazza, Rita ; Curioni, Elisabetta ; Ciani, Alberto ; Pomati, Mauro ; Maiolo, Anna Teresa. / Acute megakaryocytic leukemia in essential thrombocythemia : An unusual evolution?. In: European Journal of Haematology. 2002 ; Vol. 69, No. 2. pp. 108-111.
@article{08ec1e8b846245aba8a5b16de1cca888,
title = "Acute megakaryocytic leukemia in essential thrombocythemia: An unusual evolution?",
abstract = "Essential thrombocythemia (ET) is a chronic myeloproliferative disorder that can rarely undergo leukemic transformation either in treated (3-7{\%}) or untreated patients (1{\%}). Evolution to myeloblastic or myelomonoblastic acute leukemia is commonly described in the literature, whereas lymphatic and megakaryocytic forms are considered unusual. Here, we report three cases of acute megakaryocytic leukemia (LMA-M7) among 11 acute leukemic transformations observed in our series of 321 ET patients. LMA-M7 was diagnosed employing immunophenotyping according to FAB criteria. These recurrences of LMA M7 suggest that this kind of evolution cannot be considered rare or casual in ET.",
keywords = "Essential thrombocythemia, Evolution, Megakaryocytic leukemia",
author = "Franca Radaelli and Rita Mazza and Elisabetta Curioni and Alberto Ciani and Mauro Pomati and Maiolo, {Anna Teresa}",
year = "2002",
month = "8",
day = "1",
doi = "10.1034/j.1600-0609.2002.02734.x",
language = "English",
volume = "69",
pages = "108--111",
journal = "European Journal of Haematology",
issn = "0902-4441",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "2",

}

TY - JOUR

T1 - Acute megakaryocytic leukemia in essential thrombocythemia

T2 - An unusual evolution?

AU - Radaelli, Franca

AU - Mazza, Rita

AU - Curioni, Elisabetta

AU - Ciani, Alberto

AU - Pomati, Mauro

AU - Maiolo, Anna Teresa

PY - 2002/8/1

Y1 - 2002/8/1

N2 - Essential thrombocythemia (ET) is a chronic myeloproliferative disorder that can rarely undergo leukemic transformation either in treated (3-7%) or untreated patients (1%). Evolution to myeloblastic or myelomonoblastic acute leukemia is commonly described in the literature, whereas lymphatic and megakaryocytic forms are considered unusual. Here, we report three cases of acute megakaryocytic leukemia (LMA-M7) among 11 acute leukemic transformations observed in our series of 321 ET patients. LMA-M7 was diagnosed employing immunophenotyping according to FAB criteria. These recurrences of LMA M7 suggest that this kind of evolution cannot be considered rare or casual in ET.

AB - Essential thrombocythemia (ET) is a chronic myeloproliferative disorder that can rarely undergo leukemic transformation either in treated (3-7%) or untreated patients (1%). Evolution to myeloblastic or myelomonoblastic acute leukemia is commonly described in the literature, whereas lymphatic and megakaryocytic forms are considered unusual. Here, we report three cases of acute megakaryocytic leukemia (LMA-M7) among 11 acute leukemic transformations observed in our series of 321 ET patients. LMA-M7 was diagnosed employing immunophenotyping according to FAB criteria. These recurrences of LMA M7 suggest that this kind of evolution cannot be considered rare or casual in ET.

KW - Essential thrombocythemia

KW - Evolution

KW - Megakaryocytic leukemia

UR - http://www.scopus.com/inward/record.url?scp=0036699502&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036699502&partnerID=8YFLogxK

U2 - 10.1034/j.1600-0609.2002.02734.x

DO - 10.1034/j.1600-0609.2002.02734.x

M3 - Article

C2 - 12366715

AN - SCOPUS:0036699502

VL - 69

SP - 108

EP - 111

JO - European Journal of Haematology

JF - European Journal of Haematology

SN - 0902-4441

IS - 2

ER -