Acute modulation of cortical oscillatory activities during short trains of high-frequency repetitive transcranial magnetic stimulation of the human motor cortex: A combined EEG and TMS study

Giorgio Fuggetta, Enea F. Pavone, Antonio Fiaschi, Paolo Manganotti

Research output: Contribution to journalArticle

Abstract

In this study, a combined repetitive transcranial magnetic stimulation/electroencephalography (rTMS/EEG) method was used to explore the acute changes of cortical oscillatory activity induced by intermittent short trains of high-frequency (5-Hz) rTMS delivered over the left primary motor cortex (M1). We evaluated the electrophysiological reaction to magnetic stimulation during and 2-4 s after 20 trains of 20-pulses rTMS, using event-related power (ERPow) that reflects the regional oscillatory activity of neural assemblies, and event-related coherence (ERCoh) that reflects the interregional functional connectivity of oscillatory neural activity. These event-related transformations were for the upper α (10-12 Hz) and β (18-22 Hz) frequency ranges, respectively. For the α band, threshold rTMS and subthreshold rTMS induced an ERPow increase during the trains of stimulation mainly in frontal and central regions ipsilateral to stimulation. For the β band, a similar synchronization of cortical oscillations for both rTMS intensities was seen. Moreover, subthreshold rTMS affected α-band activity more than threshold rTMS, inducing a specific ERCoh decrease over the posterior regions during the trains of stimulation. For β band, the decrease in functional coupling was observed mainly during threshold rTMS. These findings provide a better understanding of the cortical effects of high-frequency rTMS, whereby the induction of oscillations reflects the capacity of electromagnetic pulses to alter regional and interregional synaptic transmissions of neural populations.

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalHuman Brain Mapping
Volume29
Issue number1
DOIs
Publication statusPublished - Jan 2008

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Cortical Synchronization
Transcranial Magnetic Stimulation
Electromagnetic Phenomena
Motor Cortex
Synaptic Transmission
Electroencephalography
Population

Keywords

  • Cerebral cortex
  • Connectivity
  • EEG-TMS combination
  • GABAergic modulation
  • Motor cortex
  • Oscillations

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Radiological and Ultrasound Technology

Cite this

Acute modulation of cortical oscillatory activities during short trains of high-frequency repetitive transcranial magnetic stimulation of the human motor cortex : A combined EEG and TMS study. / Fuggetta, Giorgio; Pavone, Enea F.; Fiaschi, Antonio; Manganotti, Paolo.

In: Human Brain Mapping, Vol. 29, No. 1, 01.2008, p. 1-13.

Research output: Contribution to journalArticle

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