Acute myelogenous leukemia with translocation t(8;21): A cytogenetic study of seven cases

M. Sessarego, C. Mareni, C. Panarello, L. Garrè, F. Frassoni, P. Boccaccio, F. Ajmar

Research output: Contribution to journalArticle

Abstract

Seven cases of acute nonlymphoblastic leukemia showing t(8;21)(q22;q22) at diagnosis are described. Involvement of a sex chromosome was found in all patients (in six cases as a loss, and in one as a Y duplication), thus, confirming the suggestion of a correlation between these two chromosomal abnormalities. The constitutional folic acid-sensitive fragile site fra(8)(q22) was not detected, in spite of careful analysis of over 300 metaphases of cells grown in folic acid-free medium. Morphologic diagnoses and clinical aspects are briefly discussed.

Original languageEnglish
Pages (from-to)363-368
Number of pages6
JournalCancer Genetics and Cytogenetics
Volume20
Issue number3-4
DOIs
Publication statusPublished - Feb 15 1986

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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