Acute myelogenous leukemia with translocation t(8;21): A cytogenetic study of seven cases

M. Sessarego, C. Mareni, C. Panarello, L. Garrè, F. Frassoni, P. Boccaccio, F. Ajmar

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Abstract

Seven cases of acute nonlymphoblastic leukemia showing t(8;21)(q22;q22) at diagnosis are described. Involvement of a sex chromosome was found in all patients (in six cases as a loss, and in one as a Y duplication), thus, confirming the suggestion of a correlation between these two chromosomal abnormalities. The constitutional folic acid-sensitive fragile site fra(8)(q22) was not detected, in spite of careful analysis of over 300 metaphases of cells grown in folic acid-free medium. Morphologic diagnoses and clinical aspects are briefly discussed.

Original languageEnglish
Pages (from-to)363-368
Number of pages6
JournalCancer Genetics and Cytogenetics
Volume20
Issue number3-4
DOIs
Publication statusPublished - Feb 15 1986

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Folic Acid
Acute Myeloid Leukemia
Cytogenetics
Sex Chromosomes
Metaphase
Chromosome Aberrations

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Acute myelogenous leukemia with translocation t(8;21) : A cytogenetic study of seven cases. / Sessarego, M.; Mareni, C.; Panarello, C.; Garrè, L.; Frassoni, F.; Boccaccio, P.; Ajmar, F.

In: Cancer Genetics and Cytogenetics, Vol. 20, No. 3-4, 15.02.1986, p. 363-368.

Research output: Contribution to journalArticle

Sessarego, M. ; Mareni, C. ; Panarello, C. ; Garrè, L. ; Frassoni, F. ; Boccaccio, P. ; Ajmar, F. / Acute myelogenous leukemia with translocation t(8;21) : A cytogenetic study of seven cases. In: Cancer Genetics and Cytogenetics. 1986 ; Vol. 20, No. 3-4. pp. 363-368.
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