Acute myeloid leukemia

Correlation between FAB classification criteria and surface antigenic markers

N. Cascavilla, M. M. Greco, S. Ladogana, A. La Sala, L. Melillo, P. Musto, M. Nobile, A. Piano, V. M. Valori, M. Carotenuto

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Sixty-one patients with acute myeloid leukemia (AML) or acute unclassifiable leukemia (AUL) at presentation were studied, and FAB criteria were correlated with surface antigen expression recognized by MY9, (CD33), MY7 (CD13), MY4 (CD14), OKM5, OKDR, OKT9, OKT10 (CD38), HPCA-1 (CD34), SOL34, GpIb (CDw42), CALLA (CD10), B4 (CD19), B1 (CD20), Leu9 (CD7) and OKT3 (CD3). Results showed good agreement between FAB suclasses and antigenic phenotypes in 90% of 59 AML, though a direct correlation between cytochemical and immunological reactions was lacking. In 2 AUL immunological investigations permitted correct diagnosis and efficacious therapy. In the M2 subclass, an MY4-and OKM5-positive blastic fraction over 20% was frequently observed, in agreement only with higher serum lysozyme levels. On the whole, results demonstrate: a) considerable leukemic population heterogeneity; b) unrelated expression of cytochemical and antigenic markers; c) strength of immunological analysis for the characterization of the ontogenic stage of myeloid blasts.

Original languageEnglish
Pages (from-to)37-42
Number of pages6
JournalHaematologica
Volume73
Issue number1
Publication statusPublished - 1988

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Acute Myeloid Leukemia
Leukemia
Muromonab-CD3
Population Characteristics
Surface Antigens
Muramidase
Phenotype
Serum
Therapeutics

ASJC Scopus subject areas

  • Hematology

Cite this

Cascavilla, N., Greco, M. M., Ladogana, S., La Sala, A., Melillo, L., Musto, P., ... Carotenuto, M. (1988). Acute myeloid leukemia: Correlation between FAB classification criteria and surface antigenic markers. Haematologica, 73(1), 37-42.

Acute myeloid leukemia : Correlation between FAB classification criteria and surface antigenic markers. / Cascavilla, N.; Greco, M. M.; Ladogana, S.; La Sala, A.; Melillo, L.; Musto, P.; Nobile, M.; Piano, A.; Valori, V. M.; Carotenuto, M.

In: Haematologica, Vol. 73, No. 1, 1988, p. 37-42.

Research output: Contribution to journalArticle

Cascavilla, N, Greco, MM, Ladogana, S, La Sala, A, Melillo, L, Musto, P, Nobile, M, Piano, A, Valori, VM & Carotenuto, M 1988, 'Acute myeloid leukemia: Correlation between FAB classification criteria and surface antigenic markers', Haematologica, vol. 73, no. 1, pp. 37-42.
Cascavilla, N. ; Greco, M. M. ; Ladogana, S. ; La Sala, A. ; Melillo, L. ; Musto, P. ; Nobile, M. ; Piano, A. ; Valori, V. M. ; Carotenuto, M. / Acute myeloid leukemia : Correlation between FAB classification criteria and surface antigenic markers. In: Haematologica. 1988 ; Vol. 73, No. 1. pp. 37-42.
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