Acute myocardial infarction after sumatriptan administration for cluster headache

E. Anghileri, V. Toso, F. Perini

Research output: Contribution to journalArticlepeer-review


The pain of cluster headache attacks is severe, excruciating and selectively responsive to subcutaneous sumatriptan. Serious cardiovascular events attributed to sumatriptan are extremely rare and have most often been reported in patients at significant cardiovascular risk, or in overt cardiovascular disease. They also have occurred, however, in patients without evidence of cardiovascular disease. We describe a 42-year-old man with episodic cluster headache without history of coronary artery disease who was admitted to our coronary care unit for acute myocardial infarction after 3 h of subcutaneous injection of sumatriptan. During hospitalisation cluster headache attacks were successfully treated with e.v. indomethacin.

Original languageEnglish
Pages (from-to)456-459
Number of pages4
JournalNeurological Sciences
Issue number6
Publication statusPublished - Feb 2006


  • Episodic cluster headache
  • Indomethacin
  • Parecoxib
  • Sumatriptan

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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