Acute myocardial infarction complicating ischemic stroke: is there room for cangrelor?

Nuccia Morici, Stefano Nava, Alice Sacco, Giovanna Viola, Jacopo Oreglia, Paolo Meani, Fabrizio Oliva, Marco Ranucci, Sergio Leonardi, Roberta Rossini

Research output: Contribution to journalArticlepeer-review


Acute myocardial infarction (AMI) complicating ischemic stroke is a well known and undertreated event. A conservative management is not infrequent in these settings, due to the fear of hemorrhagic complications related to antithrombotic therapy. Notably, an invasive approach with a primary percutaneous coronary intervention (PCI) has been shown to be associated with a lower in-hospital mortality in patients with concomitant ischemic stroke and AMI. The optimal antiplatelet regimen in these cases has been not clearly defined, yet. We report two cases of patients with AMI complicating ischemic stroke, successfully treated with cangrelor infusion, which was started during PCI and maintained up to 48 h at bridge therapy dosage (0.75 mcg/kg/min). Both patients underwent successful PCI in the acute phase, and neither ischemic nor hemorrhagic complications occurred during in-hospital stay.

Original languageEnglish
Pages (from-to)120-123
Number of pages4
Issue number1
Publication statusPublished - 2020


  • Adenosine Monophosphate/administration & dosage
  • Aged
  • Aged, 80 and over
  • Biomarkers
  • Disease Management
  • Female
  • Humans
  • Male
  • Myocardial Infarction/complications
  • Percutaneous Coronary Intervention/adverse effects
  • Platelet Aggregation Inhibitors/administration & dosage
  • Purinergic P2Y Receptor Antagonists/administration & dosage
  • Stroke/diagnosis
  • Time-to-Treatment
  • Tomography, X-Ray Computed
  • Treatment Outcome


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